PMID: 9194537Jun 1, 1997Paper

Effects of nisoldipine on cytosolic calcium, platelet aggregation, and coagulation/fibrinolysis in patients with coronary artery disease

Angiology
A FujinishiA Kuroiwa

Abstract

The effect of nisoldipine, a dihydropyridine Ca2+ antagonist, on the platelet cytosolic Ca2+ concentration ([Ca2+]i), platelet aggregation, and various coagulation and fibrinolysis parameters was assessed in normotensive patients with coronary artery disease (CAD). Eleven patients with angiographically confirmed CAD (4 men, 7 women aged 67.3 +/- 5.4 years) were administered nisoldipine at 10 mg/day for two weeks. The [Ca2+]i was determined by use of fura2-loaded platelets, platelet aggregation was measured with an aggregometer, and coagulation/fibrinolysis parameters were measured by standard methods. Nisoldipine did not significantly affect blood pressure or heart rate. However, the [Ca2+]i decreased significantly (P<0.05) and platelet aggregation was also significantly inhibited. Plasma D-dimer levels decreased significantly (P<0.01). Thus, nisoldipine not only suppressed platelet activation but also affected the coagulation system, suggesting that it is not only a vasodilator and platelet inhibitor but also an antithrombotic agent.

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Citations

Aug 10, 2011·Chinese Journal of Integrative Medicine·Yue LiuKe-ji Chen
Jun 30, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Roberto Fogari, Annalisa Zoppi
Dec 28, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mervyn D I VergouwenYvo Bwem Roos
Aug 2, 2007·Hematology/oncology Clinics of North America·Yu-Min P Shen, Eugene P Frenkel
Apr 21, 1999·Lancet·K Kario, T G Pickering
Mar 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Yue LiuKe-Ji Chen
Jan 17, 2020·Acta Biochimica Et Biophysica Sinica·Xin GuoLe Gui

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