Effects of nitrazepam on nocturnal scratching in adults with atopic dermatitis: a double-blind placebo-controlled crossover study

The British Journal of Dermatology
T EbataM Niimura

Abstract

We investigated the effect of nitrazepam on nocturnal scratching in 10 adult out-patients with atopic dermatitis (AD) using a double-blind placebo-controlled crossover method. Patients were given either nitrazepam (Benzalin tablets containing 5 mg nitrazepam) or a placebo on 3 successive nights, with a washout interval of 4 days. We used an infrared video camera to identify bouts of scratching lasting more than 5 s. These were counted and the duration of all the bouts of scratching (total scratching time, TST) was calculated. The percentage of TST to total recording time (TST%) was used as an index of nocturnal scratching. The frequency with which bouts of scratching (bouts/h) occurred was reduced by 10 mg nitrazepam (7.7 +/- 3.6 with nitrazepam vs. 9.6 +/- 3.6 with placebo, P < 0.05). However, the mean duration (s/bout) of the bouts of scratching was longer with 10 mg nitrazepam (32.3 +/- 23.4 with nitrazepam vs. 19.1 +/- 10.0 with placebo, P < 0.05). As a result, there was no significant difference between TST% (6.5 +/- 4.2 with nitrazepam vs. 5.4 +/- 3.8 with placebo, not significant). All the above values are mean +/- SD. The degree of itching and the condition of the AD did not change during the 2 weeks of the study. We co...Continue Reading

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Citations

Jul 27, 1999·The British Journal of Dermatology·T EbataM Niimura
Dec 22, 1999·Clinical and Experimental Dermatology·J L Rees, A Laidlaw
Apr 1, 2014·Journal of Pain and Symptom Management·Paul HowardAndrew Wilcock
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Nov 10, 2015·The Journal of Allergy and Clinical Immunology·Anna B FishbeinAmy S Paller
Jul 8, 2005·Psychosomatics·Ramona MahtaniShree Bhalerao
Mar 25, 2018·Pediatric Dermatology·Devika PatelTor Shwayder
Jun 27, 2018·Pediatric Dermatology·Emily BoozalisShawn G Kwatra
Sep 17, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Aleksi J HendricksVivian Y Shi
Aug 23, 2016·The British Journal of Dermatology·H NankervisH C Williams
Jan 29, 2018·Neuroscience and Biobehavioral Reviews·Kristen M Sanders, Tasuku Akiyama
Dec 16, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Fatima BawanyWilfred R Pigeon
Jul 22, 2021·The Journal of Dermatology·Takahiro SatohIchiro Katayama

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