Effects of nitric oxide availability on responses of spinal wide dynamic range neurons to excitatory amino acids

European Journal of Pharmacology
D BudaiA A Larson

Abstract

The role of nitric oxide (NO) in responses of spinal dorsal horn neurons to excitatory amino acids and to cutaneous mechanical stimuli was examined. Extracellular recordings were made from wide dynamic range neurons excited with iontophoretically applied excitatory amino acid agonists, N-methyl-D-aspartate (NMDA) and (R,S)-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) or kainic acid. Nitric oxide availability was decreased by iontrophoretic application of NO synthase inhibitors, N omega-nitro-L-arginine methyl ester (L-NAME) or L-N5-(1-iminoethyl)ornithine (L-NIO), or elevated by the NO donating compound, S-nitroso-N-penicillamine (SNAP). When cells were excited with successive application of NMDA and non-NMDA excitatory amino acid receptor agonists, application of NO synthase inhibitors led to a decrease in responses to NMDA in 60% of neurons. In more than a third of the cells tested, inhibition of NO synthase caused reciprocal changes in responses to glutamate receptor agonists: NMDA-evoked responses were significantly decreased whereas responses to the non-NMDA receptor agonists (AMPA or kainic acid) were increased. Application of the NO donating compound, S-nitroso-N-penicillamine, revealed an opposite te...Continue Reading

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Citations

Mar 29, 2001·Autonomic Neuroscience : Basic & Clinical·L B Wilson, J Engbretson
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·C A FairbanksG L Wilcox
Apr 18, 2008·British Journal of Anaesthesia·R D'Mello, A H Dickenson
Feb 4, 2014·European Journal of Pharmacology·Mariana Martins Gomes PinheiroPatrícia Dias Fernandes
May 20, 2015·Pharmacology, Biochemistry, and Behavior·Thais Biondino Sardella GiornoPatricia Dias Fernandes
May 29, 2004·Neuropharmacology·Geoffrey Andrew LambertAlessandro Stefano Zagami
Jul 15, 2015·Autonomic Neuroscience : Basic & Clinical·Dmitry A ChistiakovYuri V Bobryshev
Dec 21, 2006·Somatosensory & Motor Research·Angelo GarifoliVincenzo Perciavalle
Dec 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Ana Carolina Rodrigues DiasSteven W Mifflin
Jun 11, 1999·The American Journal of Physiology·L B WilsonA D Crews

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