PMID: 11774815Jan 5, 2002Paper

Effects of nitric oxide (NO) on the cardiac function in severely scalded rats

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
T WangY Chen

Abstract

To investigate the effects of NO on the cardiac function in severely scalded rats and to elucidate its mechanism. Ninety Sprague-Dawley (SD) rats inflicted with 30% TBSA III degree scalding were employed as the model and divided randomly into five groups, i.e. burn (B), shamburn (SB), L-arginine (L-Arg), N-nitroso-L-argininemethylester (L-NAME) and L-Arg + L-NAME groups. Cardiac functional indices, myocardial content of malondialdehyde (MDA) and myocardial Ca (calcium) transport were examined in the rats of all the groups, respectively. Compared to those in B group, the mean arterial pressure (MAP), left ventricular summit pressure (LVSP), the +/- dp/dt max in left ventricle pressure and the cardiac Lo in L-NAME group increased obviously. While those in L-Arg group decreased significantly but those in L-Arg + L-NAME group exhibited no remarkable change. The MDA content in L-NAME group was evidently lower than that in B group, while the calcium transport index of sarcoplasmic reticulum in L-NAME group increased obviously. Nitric oxide, massively produced postburn, exerted inhibitory effects on cardiac function by means of the cytotoxicity of its owns and other free radicals, which might be closely related to the decrease of its ...Continue Reading

Related Concepts

Arginine hydrochloride
Diastolic Blood Pressure
Burn Injury
Calcium
Drug Augmentation
Heart
Sodium Malondialdehyde
Myocardium
Nitric Oxide
Systole

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