PMID: 9439387Jan 24, 1998Paper

Effects of nitric oxide on blood flow and mucociliary activity in the human nose

The Annals of Otology, Rhinology, and Laryngology
T Runer, S Lindberg

Abstract

In an animal model, nitric oxide (NO) has been shown to increase mucociliary activity in vivo and ciliary beat frequency in vitro. The aim of the present study was to investigate the effects of NO on blood flow and mucociliary activity in the human nose. The concentration of NO in nasal air was measured with a chemiluminescence technique after nebulizing the NO donor sodium nitroprusside (SNP) at a dose of 3.0 mg into the nose in six volunteers, and was found to increase by 50.1% +/- 10.0% (mean +/- SEM; p < .001) after the SNP challenge. Blood flow measured by laser Doppler flowmetry increased by 67.3% +/- 15.5% (p < .05) after challenge with SNP at 1.0 mg, and by 75.4% +/- 18.5% at 3.0 mg (p < .01; n = 6). The higher dose, which produced no subjective side effects, was then used in the mucociliary experiments. The maximum increase in nasal mucociliary activity was 57.2% +/- 6.7% at 3.0 mg of SNP (n = 5). The findings support the view that NO regulates mucociliary activity and blood flow in the human nasal mucosa.

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Citations

Apr 19, 2003·American Journal of Respiratory and Critical Care Medicine·Maria DejaKlaus Lewandowski
Sep 11, 2002·Acta Oto-laryngologica·Masanobu ImadaJun Iwamoto
Feb 25, 2000·Acta Oto-laryngologica·T Runer, S Lindberg
Jul 14, 2000·Acta Oto-laryngologica·J PalmJ Lundberg
Sep 17, 2004·Acta Oto-laryngologica·Alessandra Rinaldo, Alfio Ferlito
Feb 13, 2013·American Journal of Otolaryngology·A A GungorL Kuo
Oct 28, 2008·Respiratory Physiology & Neurobiology·William E HoldenGeorge D Giraud
Oct 28, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jon O Lundberg
Jul 15, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Camille JardelezaPeter-John Wormald
Nov 13, 2001·Allergy·M JorissenT Willems
Sep 30, 2000·Clinical Otolaryngology and Allied Sciences·P J Conboy, N S Jones
Aug 11, 2011·International Archives of Allergy and Immunology·G SahinO Pfaar
Jan 10, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Eun-ju JeonKi-Hong Chang
Mar 16, 2000·The Laryngoscope·J S HaightN Zamel
Jul 26, 2018·International Forum of Allergy & Rhinology·Waleed M AbuzeidJoel M Friedman
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Nov 7, 2019·Journal of Clinical Medicine·Diana Vlad, Silviu Albu
Feb 15, 2001·American Journal of Otolaryngology·P G DjupeslandJ S Haight

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