Effects of nitric oxide on dentate gyrus cell proliferation after seizures induced by pentylenetrazol in the adult rat brain

Neuroscience Letters
Wen JiangXia Zhang

Abstract

Epileptic seizures have been shown to increase the proliferation of granule cell precursors in the adult brain, but the underlying mechanisms remain largely unknown. This study examined the effect of nitric oxide (NO) on the proliferation of granule cell precursors in adult rats after pentylenetrazol (PTZ)-induced generalized clonic seizures. Using systemic bromodeoxyuridine (BrdU) to label dividing cells, we found that injection of the neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (50 mg/kg i.p.) 10 min before PTZ significantly reduced the number of BrdU labeled cells in the dentate gyrus 3, 7, and 14 days after seizures (P < 0.05). Administration of the inducible NOS (iNOS) inhibitor aminoguanidine (100 mg/kg i.p.) also significantly inhibited the proliferation rate of neural precursor cells in the dentate gyrus at various time points after PTZ-induced seizures. Our findings suggest that epileptic seizures lead to increased cell proliferation in the adult rat dentate gyrus through NO-dependent mechanisms. Both the NO originating from nNOS and iNOS may be involved in brain repair after seizures.

References

Jan 1, 1995·Annual Review of Physiology·S S Gross, M S Wolin
May 1, 1993·The Journal of Comparative Neurology·J G ValtschanoffH H Schmidt
Aug 12, 1993·Nature·S H Snyder
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·H Y YunT M Dawson
Feb 1, 1997·Nitric Oxide : Biology and Chemistry·J R Lancaster
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·E GouldE Fuchs
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·D R Kornack, P Rakic
Jun 24, 2000·Brain Research·B Moreno-LópezC Estrada
Jun 22, 2002·Annals of the New York Academy of Sciences·Ankica JelenkovićB Bosković
Dec 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kenshi KanekoHirotada Fujii

❮ Previous
Next ❯

Citations

Oct 9, 2007·Cell and Tissue Research·Joanne C Conover, Ryan Q Notti
Nov 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Hai-xia LuYong Liu
Sep 22, 2012·Stem Cells International·Bruno P CarreiraInês M Araújo
Oct 10, 2014·Journal of Neuroinflammation·Ying-Ying ZouEng-Ang Ling
Jun 28, 2005·The European Journal of Neuroscience·M CayreA Strambi
Oct 30, 2008·Medicinal Research Reviews·Mark M Bailey, Cory J Berkland
Oct 31, 2012·Neuropathology and Applied Neurobiology·Y-Y ZouE-A Ling
Oct 26, 2005·Neurobiology of Disease·Terhi J PirttiläAsla Pitkänen
Feb 20, 2014·Stem Cells International·Ana I SantosInês M Araújo
Sep 13, 2011·Epilepsy & Behavior : E&B·V A AniolN V Gulyaeva
Aug 3, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Carmen Estrada, Maribel Murillo-Carretero
Jan 13, 2006·Epilepsy Research·Noushin Yahyavi-Firouz-AbadiAhmad Reza Dehpour
Nov 18, 2005·Brain Research. Brain Research Reviews·Antonio CárdenasIgnacio Lizasoain

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.