PMID: 8582980Jul 1, 1995Paper

Effects of nitric oxide on human spermatozoa: evidence that nitric oxide decreases sperm motility and induces sperm toxicity

Human Reproduction
M RosselliP J Keller

Abstract

Endogenous nitric oxide (NO) is an important functional mediator in several physiological systems, including the reproductive system. However, when generated in excessive amounts for long periods, mainly during immunological reactions, NO is cytotoxic and cytostatic for invading microbes, as well as for the cells generating it and the tissues present around it. Since infertility associated with urogenital tract infection in males and females is also accompanied by reduced sperm motility and viability, it is possible that reduced fertility in these patients is due to NO-induced sperm toxicity. We therefore evaluated the direct effects of NO, chemically derived from S-nitroso-N-acetylpenicillamine (SNAP, 0.012-0.6 mM) and sodium nitroprusside (SNP, 0.25-2.5 mM), on the motility and viability of human spermatozoa. Furthermore, we tested whether inhibition of NO synthesis prevents sperm motility and viability by incubating washed total cells present in the semen (spermatozoa, round cells) with N-nitro-L-arginine-methyl-ester (L-NAME), a NO synthesis inhibitor. Treatment of purified spermatozoa with SNAP or SNP decreased forward progressive sperm motility and straight line velocity, and also increased the percentage of immotile sper...Continue Reading

Citations

Jun 18, 1998·Andrologia·F R Ochsendorf
Aug 26, 2000·Archives of Andrology·L Sliwa, E Stochmal
Aug 31, 2002·Endocrine Reviews·Alberto RevelliIlan Tur-Kaspa
Feb 19, 2004·Archives of Pharmacal Research·Bo Hyun KimYoung Kug Choo
Feb 5, 2004·Journal of Andrology·Giancarlo BalerciaLaura Mazzanti
May 14, 2004·International Journal of Andrology·Zafer TürkyilmazNuri Kale
Aug 23, 2007·Asian Journal of Andrology·Srinivas PentyalaS Ali Khan
Jul 4, 2008·International Journal of Impotence Research·T Mostafa
Jun 15, 2007·Pakistan Journal of Biological Sciences : PJBS·Ali Karimi Goudarzi, Hossein Hassanpour
Jun 13, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Hou-Qun YingZhou-Cun A
May 2, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S EskiocakS Gulen
Dec 19, 2007·Asian Journal of Andrology·F DimitriadisN Sofikitis
Jul 15, 2007·Pakistan Journal of Biological Sciences : PJBS·Hossein HassanpourAtefe Aminian
Jan 12, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Qiong LuoHe-Feng Huang
Mar 8, 2014·British Journal of Pharmacology·B BuzadzicV Otasevic
Nov 21, 2012·Nature Reviews. Urology·Ashok AgarwalSandro C Esteves
Jul 22, 2019·Journal of Assisted Reproduction and Genetics·Florentin-Daniel StaicuCarmen Matás Parra
Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·R MiddendorffM S Davidoff
May 5, 2005·Current Opinion in Obstetrics & Gynecology·Ioannis M MatalliotakisDimitrios K Panidis
Jun 3, 2004·Human & Experimental Toxicology·W D RatnasooriyaM G Dharmasiri
Mar 4, 2008·Archives of Andrology·Serge Carreau, Galeraud-Denis Isabelle
May 22, 2007·Biochemical Society Transactions·S CarreauI Galeraud-Denis
Sep 3, 2014·Andrology·M S RahmanM-G Pang
May 18, 2017·Reproduction in Domestic Animals = Zuchthygiene·T M El-SherryM Abdelgawad
Mar 22, 2020·International Journal of Molecular Sciences·Sara Miguel-JiménezRosaura Pérez-Pe
May 23, 2001·Biology of Reproduction·A RevelliD Ghigo
Jul 28, 2004·Archives of Andrology·R ReyesN M Delgado
Nov 24, 2004·Archives of Andrology·Gwo-Jang WuYi-Chun Huang
Jun 19, 2007·International Journal of Andrology·Graciela E Hurtado de CatalfoCarlos A Marra
Oct 2, 2009·Journal of Endocrinological Investigation·B BoggiaM De Rosa
Jul 31, 2007·International Journal of Toxicology·Recep KutlubayOmer Levent Tuncay
Aug 29, 2017·The Journal of Reproduction and Development·Xiaoxia RenDong Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.