PMID: 7545764Aug 1, 1995Paper

Effects of nitric oxide synthase inhibition on regional blood flow in a porcine model of endotoxic shock

The Journal of Trauma
P J OffnerB A Pruitt

Abstract

The results of early studies suggest that nitric oxide (NO) synthesis inhibition may be therapeutic in sepsis, but recent data indicate that NO inhibition may be harmful. This study investigates the effects of NO synthesis inhibition with N-nitro-L-arginine methyl ester (NAME) on regional blood flow following endotoxemia. Anesthetized, instrumented swine were randomly divided into four groups. Controls received normal saline resuscitation (NSR) at 1 cc/kg/min beginning at T0. The lipopolysaccharide group (LPS) received NSR and Escherichia coli LPS, 200 micrograms/kg at T0. The LPS+NAME group received NSR and LPS at T0, plus NAME (50 micrograms/kg/min) starting at T1. The NAME group received only NSR and NAME. Hemodynamic data, regional blood flow, and gastric intramucosal pH (pHi) were measured hourly. LPS increased renal and carotid blood flow consistent with a hyperdynamic state. Mesenteric blood flow was decreased. Treatment of endotoxic animals with NAME decreased renal and carotid blood flow. Mesenteric blood flow and gastric pHi were improved by NAME. NO inhibition in endotoxic shock results in decreased carotid and renal blood flow, by decreasing cardiac output. Mesenteric blood flow and perfusion were improved; however,...Continue Reading

References

Sep 1, 1978·The Journal of Surgical Research·J L FergusonH I Miller
Nov 1, 1992·Critical Care Medicine·B G HarbrechtR L Simmons
Jan 1, 1992·Cardiovascular Research·C E WrightS Moncada
Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E KoźniewskaT Styś
Jun 1, 1992·Hypertension·A AlberolaF J Salazar
Aug 16, 1991·European Journal of Pharmacology·H M LoickD L Herndon
Aug 15, 1991·Biochemical and Biophysical Research Communications·R E Klabunde, R C Ritger
Nov 1, 1991·Annals of Surgery·J B OchoaA B Peitzman
May 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C González, C Estrada
Dec 1, 1990·British Journal of Pharmacology·I R HutchesonN K Boughton-Smith
May 1, 1990·Hypertension·S M GardinerS Moncada
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
Oct 1, 1988·Hypertension·S MoncadaE A Higgs
Jun 1, 1969·Circulation Research·F WylerK L Melmon
Jul 1, 1970·The American Journal of Physiology·F WylerA M Rudolph
Apr 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·C M GrumD R Dantzker
Feb 1, 1994·Archives of Surgery·F M RobertsonB A Pruitt
Feb 1, 1994·Archives of Surgery·E A MinnardJ M Daly
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D A PelligrinoR F Albrecht
May 1, 1993·Critical Care Medicine·J A LorenteD Liste

❮ Previous
Next ❯

Citations

May 1, 1997·Disease-a-month : DM·R G KilbournC Szabó
Oct 22, 1998·Critical Care Medicine·E SilvaJ L Vincent
Jan 11, 2000·Critical Care Medicine·B E Van Hoozen, T E Albertson
Jun 12, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D A DawsonJ M Hallenbeck
Jan 12, 2007·The Journal of Trauma·Homer C TienFrederick D Brenneman
Jun 3, 1999·American Journal of Respiratory and Critical Care Medicine·K TrägerB Santak
Sep 3, 2005·Critical Care : the Official Journal of the Critical Care Forum·Christoph LangenbergStanislao Morgera
Jul 11, 2008·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Dietmar TamandlPeter Goetzinger
Mar 18, 2015·Acta Anaesthesiologica Scandinavica·B BänzigerS M Jakob
May 13, 2006·Nephron. Physiology·Christoph LangenbergStanislao Morgera
Apr 22, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Qian-Yi PengUNKNOWN Chinese Critical Ultrasound Study Group
Oct 9, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kirsten MøllerBente Klarlund Pedersen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.