PMID: 7543646Jan 1, 1995Paper

Effects of nitric oxide synthesis inhibition with or without nitric oxide inhalation on responses to systemic cocaine administration in rats

Life Sciences
J E HeavnerM Pitkänen

Abstract

The effects of N omega-nitro-L-arginine methyl ester (L-NAME) i.v. and nitric oxide (NO) inhalation on integrated systemic responses to cocaine were studied in lightly anesthetized, paralyzed, and mechanically ventilated rats. Cocaine (4 mg/kg/min i.v.) produced seizures then isoelectric electrocephalographic (isoEEG) activity as well as an initial increase in systolic blood pressure and heart rate, then progressive cardiovascular system depression culminating in asystole. Pretreatment with L-NAME (2 mg/kg/min i.v.) for 30 min significantly reduced the incidence of seizure as compared to saline treated animals (saline 7/8; L-NAME 3/8). Doses of cocaine that produced arrhythmias, isoEEG and asystole were significantly lower in the L-NAME treated animals as compared to the saline group. L-NAME did not affect peak systolic blood pressure and heart rate responses to cocaine. No inhalation (80 ppm) did not affect CNS and cardiovascular responses to cocaine in control animals but enhanced the effects of L-NAME on cocaine toxicity. The results show that pretreatment with L-NAME reduces the central nervous system stimulatory effect of cocaine (reduced seizure incidence) and enhances its depressant effect on both the central nervous sys...Continue Reading

References

Oct 7, 1983·Journal of Chromatography·R C Baselt
Nov 1, 1993·Cardiovascular Research·P C Ursell, M Mayes
Sep 1, 1963·Anesthesiology·D M STEWARTE F WOODS

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Citations

Mar 7, 2003·European Journal of Pharmacology·John B WilliamsMark M Knuepfer
Jul 19, 2000·Pharmacology, Biochemistry, and Behavior·B Shi, J E Heavner
Jul 27, 1999·Pharmacology, Biochemistry, and Behavior·M M Knuepfer, P J Mueller
Feb 11, 2003·Pharmacology & Therapeutics·Mark M Knuepfer
Apr 9, 1999·Anesthesia and Analgesia·J E HeavnerM Pitkänen
Mar 26, 1998·Journal of Cardiovascular Pharmacology·M M KnuepferP J Mueller

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