Effects of nitroglycerin on regional O2 supply and O2 consumption in reperfused dog myocardium

European Journal of Pharmacology
J Joselevitz-GoldmanH R Weiss

Abstract

This study was designed to assess whether nitroglycerin would improve the relationship between O2 supply and O2 consumption in the reperfused ischemic dog myocardium. In 16 dogs the left anterior descending coronary artery was occluded for 2 h, followed by a 4 h period of reperfusion. In 8 of the 16 dogs, an infusion of 10 micrograms/kg per min of nitroglycerin was begun 10 min prior and continued during 4 h of reperfusion. Small artery and vein O2 saturations obtained microspectrophotometrically were combined with regional blood flow measurements using radioactive microspheres to determine regional myocardial O2 consumption. In both groups, 2 h of occlusion lowered the regional flow to a similar level. In the control group, 4 h of reperfusion returned the blood flow towards normal levels, from 15 +/- 20 ml/min per 100 g (mean +/- S.D.) at the end of occlusion to 57 +/- 39 in the affected area compared to 84 +/- 32 ml/min per 100 g in the nonischemic area. In nitroglycerin treated animals, the flow increase with reperfusion was similar to the control group (12 +/- 10 to 65 +/- 33 ml/min per 100 g). O2 extraction was greater in the reperfused than in the unaffected area in both groups. However, reperfused region O2 extraction wa...Continue Reading

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Sep 4, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Dominique PiquetteAndré Y Denault

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