Effects of nitroprusside on pancreatic juice secretion in the blood-perfused canine pancreas

European Journal of Pharmacology
K IwatsukiS Chiba

Abstract

The effects of nitroprusside on the secretion of pancreatic juice were investigated in preparations of isolated and blood-perfused canine pancreas. Nitroprusside (10-30 micrograms/kg) injected intravenously elicited a dose-dependent increase in pancreatic secretion accompanied by a decrease in blood pressure. Intra-arterial administration of nitroprusside (3-300 micrograms) into the perfused pancreas also elicited an increased secretion in preparations of both constant pressure and constant flow perfusion system. The results suggest that nitroprusside-induced pancreatic secretion may not result from the peripheral vasodilatation caused by nitroprusside. The effect of 100 micrograms of intra-arterial nitroprusside corresponded roughly to that of 0.1 units of secretin or 0.3 units of pancreozymin. Nitroprusside-induced secretion was inhibited by the infusion of ethacrynic acid (1 mg/min), but was not modified by phentolamine, propranolol, atropine, haloperidol, tetrodotoxin and metiamide. Nitroprusside produced a dose-dependent increase in the bicarbonate and protein concentrations in the juice, but had little effect on chloride concentration. This action was different from that of secretin or pancreozymin. It is concluded that n...Continue Reading

References

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Citations

May 1, 1986·Clinical and Experimental Pharmacology & Physiology·F YamagishiS Chiba
Jun 1, 1986·Clinical and Experimental Pharmacology & Physiology·K IwatsukiS Chiba
Sep 1, 1986·Clinical and Experimental Pharmacology & Physiology·K IwatsukiS Chiba
Mar 1, 1989·Clinical and Experimental Pharmacology & Physiology·K IwatsukiS Chiba
Jul 1, 1991·Clinical and Experimental Pharmacology & Physiology·K IwatsukiS Chiba
Jul 1, 1993·Clinical and Experimental Pharmacology & Physiology·K IwatsukiS Chiba
Sep 1, 1994·Clinical and Experimental Pharmacology & Physiology·K IwatsukiS Chiba
Dec 18, 2004·Fundamental & Clinical Pharmacology·K Iwatsuki
Dec 3, 1985·European Journal of Pharmacology·F YamagishiS Chiba
Jul 31, 1987·Biochemical and Biophysical Research Communications·H OguchiS Chiba
Oct 11, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Matthew J DiMagnoChung Owyang

Related Concepts

Metazoa
Carbonic Acid Ions
Chloride Ion Level
CCK-33
Canis familiaris
Hydromedin
Ferricyanides
Nitriate
Pancreas
Pancreatic Juice

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