PMID: 11318773Apr 25, 2001Paper

Effects of nociceptin and endomorphin 1 on the electrically stimulated human vas deferens

British Journal of Clinical Pharmacology
R BigoniD G Lambert

Abstract

To examine the effects of nociceptin (NC) and endomorphin 1 (EM1) on electrical field stimulation (EFS)-induced contractions of the human vas deferens (hVD). Concentration-response curves to NC and EM1 were constructed in the absence and in presence of peptidase inhibitors (PI). In some experiments a NC receptor antagonist, [Phe1psi(CH2-NH)Gly2]NC(1-13)NH2 [F/G], 10 microM) or naloxone (1 microM) were included. All data are mean(95%CI). In the presence of PI, NC inhibited twitches (Emax = 67(44,90)%; pEC50 = 7.28(6.95,7.61)). NC inhibition was sensitive to [F/G]. EM1 also inhibited twitches both in the absence (Emax = 82(73,91)% pEC50 = 7.07(6.92,7.22)) and presence (Emax = 83(76,90)%; pEC50 = 7.00(6.91, 7.09)) of PI. EM1 inhibition was sensitive to naloxone. These data suggest that hVD express NC and opioid receptors that inhibit neurogenic contractions.

References

Apr 29, 1996·European Journal of Pharmacology·I P Berzetei-GurskeL Toll
Sep 5, 1996·European Journal of Pharmacology·G CalòD Regoli
Mar 7, 1998·British Journal of Pharmacology·R GuerriniD Regoli
Dec 10, 1998·Critical Reviews in Neurobiology·O CivelliR Reinscheid
Apr 1, 2000·British Journal of Pharmacology·G Calo'D Regoli

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Citations

Jan 22, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Aug 7, 2002·British Journal of Pharmacology·Anna SiniscalchiClementina Bianchi
Jun 29, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·M KitayamaD G Lambert
May 29, 2015·Cell and Tissue Research·Ali Mohammed PitiaTetsuya Kohsaka
Jul 4, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·James RootCarolyn Napier

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