Abstract
The aim of this study was to investigate the effects of nomegestrol acetate (NOMAc) on the central nervous system by analyzing the neurosteroid allopregnanolone and the opioid beta-endorphin (beta-endorphin). 104 Wistar female rats were used in this study; one group of fertile and one group of ovariectomized rats were used as control. The others were ovariectomized and they underwent a 2-week oral treatment of NOMAc (0.05, 0.1, 0.2, 0.5, 1mg/kg/day), alone or with 0.05 mg/kg/day of estradiol valerate (E2V). Allopregnanolone and beta-endorphin were assessed in different brain areas and in circulation. Ovariectomy decreased allopregnanolone anywhere except in the adrenal gland and E2V reversed the effects of ovariectomy. 0.5 and 1mg/kg/day of NOMAc increased allopregnanolone levels in hippocampus. Combined administration of 1mg/kg/day of NOMAc plus E2V induced a further increase of allopregnanolone levels in hippocampus, hypothalamus, and anterior pituitary. NOMAc (1mg/kg/day) decreased the adrenal content of allopregnanolone, both by itself and associated with E2V. NOMAc increased hippocampal and hypothalamic content of beta-endorphin at the highest doses, and it increased positively E2V action, at 1mg/kg/day, also in anterior p...Continue Reading
References
Oct 1, 1982·Endocrinology·F PetragliaE E Müller
Sep 1, 1993·Endocrinology·C CorpéchotJ Sjövall
Mar 17, 1995·Life Sciences·L C SalandD Ramirez
Apr 2, 1998·Maturitas·M StomatiM Santre
Apr 16, 1998·European Journal of Endocrinology·F BernardiA R Genazzani
Jun 17, 1998·The Journal of Clinical Endocrinology and Metabolism·A R GenazzaniM Luisi
Oct 12, 2000·Neuroendocrinology·A R GenazzaniF Petraglia
Dec 16, 2003·The Journal of Steroid Biochemistry and Molecular Biology·J Shields-BotellaJ Paris
Mar 17, 2004·Fertility and Sterility·Andrea R GenazzaniMichele Luisi
Jul 16, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·N PluchinoA R Genazzani
Oct 6, 2005·Climacteric : the Journal of the International Menopause Society·R Sitruk-Ware
Apr 12, 2006·Menopause : the Journal of the North American Menopause Society·Andrea R GenazzaniHelenius J Kloosterboer
Aug 26, 2006·Neuroendocrinology·Francesca BernardiAndrea Riccardo Genazzani
Nov 1, 2006·Menopause : the Journal of the North American Menopause Society·Andrea Riccardo GenazzaniMichele Luisi
Apr 14, 2007·Endocrine Reviews·Michael SchumacherEtienne-Emile Baulieu
Citations
Oct 10, 2012·Reproductive Biology and Endocrinology : RB&E·Harry A van Diepen
Nov 3, 2010·Journal of the Neurological Sciences·Helmut Leitner
Oct 12, 2010·Contraception·Regine Sitruk-Ware, Anita Nath
Apr 23, 2009·The Journal of Steroid Biochemistry and Molecular Biology·E LenziA R Genazzani
Jan 27, 2009·Maturitas·N PluchinoA R Genazzani
Oct 1, 2011·Hormone Molecular Biology and Clinical Investigation·Andrea Riccardo GenazzaniNicola Pluchino
Jun 25, 2016·Journal of Molecular Endocrinology·Silvia GiattiMarzia Pesaresi
May 10, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Manuela NeriAnna Maria Paoletti
Sep 28, 2020·Clinical Drug Investigation·Franca Fruzzetti, Tiziana Fidecicchi
Oct 2, 2009·Peptides·Richard J Bodnar