Effects of nondipping pattern on systemic inflammation in obstructive sleep apnea

Sleep & Breathing = Schlaf & Atmung
Sevinc Sarinc UlasliMehmet Ünlü

Abstract

Obstructive sleep apnea syndrome (OSAS) is a highly prevalent chronic systemic disease in the general population with high morbidity and mortality. Nondipping pattern-failure to drop blood pressure levels in nighttime-is also seen in OSAS patients. We aim to investigate dipping and nondipping patterns of OSAS patients and to compare inflammatory markers. Patients with the confirmed diagnosis of OSAS with polysomnography underwent ambulatory blood pressure monitoring. During monitoring, patients with decreased nighttime mean systolic blood pressures 10 % or more were defined as dippers, and the patients without this amount of decrease were defined as nondippers. Peripheral venous blood samples were collected for the analysis of IL-2, IL-6, IL-8, IL-10, IL-12, and TNF-α. Results were compared with convenient statistical tests. According to monitoring results, 34 of 62 OSAS patients were dipper and 28 of 62 patients were nondipper. Demographic characteristics, OSAS severity, and Apnea Hypopnea Index were similar in both groups. When inflammatory markers were compared between two groups, IL-2 levels were found to be significantly different (p = 0.014). In conclusion, nondipping pattern appears to be associated with increased serum ...Continue Reading

References

Dec 1, 1976·Annals of Internal Medicine·A G TilkianW C Dement
Dec 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·F A TolleO N Markand
Aug 5, 1998·Current Opinion in Nephrology and Hypertension·D S SilverbergA Iaina
Oct 18, 2000·Blood Pressure Monitoring·C R JonesA H Shennan
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·E O BixlerA Kales
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Maria R BonsignoreGiovanni Bonsignore
May 14, 2003·Journal of the American College of Cardiology·Jo-Dee L LattimoreIan Wilcox
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Mar 19, 2005·Journal of Hypertension·Eoin O'BrienUNKNOWN European Society of Hypertension Working Group on Blood Pressure Monitoring
Feb 6, 2008·Proceedings of the American Thoracic Society·Naresh M Punjabi
Jun 6, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuomi Kario
Mar 4, 2010·Sleep & Breathing = Schlaf & Atmung·Alessandra QuercioliFabrizio Montecucco
Mar 11, 2010·Blood Pressure Monitoring·Wolfgang WeiMarkus van der Giet
Jul 27, 2010·Blood Pressure Monitoring·Pascal M L Franssen, Ben P M Imholz
Sep 14, 2013·Journal of Hypertension·Eoin O'BrienUNKNOWN European Society of Hypertension Working Group on Blood Pressure Monitoring
Oct 16, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Rashid NadeemRohit Loomba
Sep 15, 2014·Clinical Biochemistry·Micha T MaederChristian Mueller

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Citations

Jul 4, 2015·Sleep & Breathing = Schlaf & Atmung·Sibel ÖzdaşAfife Izbirak
Jul 7, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sevinc Sarinc UlasliMehmet Unlu
Sep 5, 2019·Journal of Clinical Medicine·Cesare CuspidiGiuseppe Mancia
Apr 9, 2020·Journal of Clinical Medicine·Yu-Shu HuangHsueh-Yu Li
Oct 6, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bradley G PhillipsRichard B Meagher

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