Effects of nonoral estradiol-micronized progesterone or low-dose oral estradiol-drospirenone therapy on metabolic variables and markers of endothelial function in early postmenopause

Fertility and Sterility
Gislaine Krolow CasanovaP M Spritzer

Abstract

To evaluate the effects of low-dose oral hormone therapy and nonoral hormone therapy on endothelial function markers and on anthropometric, metabolic, and hormonal variables in early postmenopausal women. Cross-over, randomized clinical trial. Gynecological Endocrinology Unit. Healthy postmenopausal women. Twenty patients received oral E(2) 1 mg plus drospirenone 2 mg/d for 2 months. Another group of 20 patients received 3 mg/d 17beta intranasal E(2), and then 200 mg/d vaginal micronized P for 14 days during two 28-day cycles. At the end of this period, the patients were crossed over for another 2 months. Endothelial function markers and anthropometric, metabolic, and hormonal variables before and after hormone therapy. Mean age was 51.2 +/- 2.7 years. Mean time since menopause was 23.1 +/- 10 months. After low-dose treatment, a reduction in waist circumference, waist-to-hip ratio, and high-density-lipoprotein cholesterol was observed. Triglycerides and von Willebrand factor levels decreased significantly with nonoral treatment. Fasting glucose and insulin levels did not change. In both groups, total and non-high-density-lipoprotein cholesterol levels decreased below basal levels, and endothelin-1, fibrinogen, and C-reactive pr...Continue Reading

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Citations

Jan 22, 2014·Journal of Women's Health·Katherine M NewtonAndrea Z LaCroix
Feb 14, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lisiane SmiderleSilvana Almeida
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Jul 16, 2014·Climacteric : the Journal of the International Menopause Society·G CasanovaP M Spritzer
Aug 21, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ramon B RamosPoli M Spritzer
Mar 3, 2017·The Australian & New Zealand Journal of Obstetrics & Gynaecology·John Eden
Jul 1, 2017·Expert Opinion on Drug Safety·James H PickarHugh S Taylor
Nov 28, 2018·Climacteric : the Journal of the International Menopause Society·A CoquozP Stute

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