PMID: 8946629Nov 1, 1996Paper

Effects of nonoxynol-9 on vaginal microflora and chlamydial infection in a monkey model

Sexually Transmitted Diseases
Dorothy L PattonS L Hillier

Abstract

Nonoxynol-9, an intravaginal microbicide, is chlamydiacidal in vitro but also cytotoxic. This study examines the effects of nonoxynol-9 in vivo, using a pigtail macaque model of chlamydial cervicitis. To establish a minimum infectious dose of Chlamydia trachomatis in the macaque, and to observe the effects of a single dose of nonoxynol-9 on efficiency of chlamydial infection, vaginal microflora, and cervicovaginal irritation. The effects of 4% nonoxynol-9, C. trachomatis (5,000 or 10,000 IFU) or both nonoxynol-9 application and chlamydial infection were studied in 17 macaques. Following a single application of nonoxynol-9, chlamydial infection was prevented in 4 of 6 monkeys infected with 10,000 IFU; there was a transient decrease in anaerobic gram-negative rods (P < 0.05) and Peptostreptococci (P > 0.05), but no change in Lactobacillus. Mild cervicovaginal irritation was observed in the monkeys. A single dose of nonoxynol-9 causes minimal vaginal flora and epithelial irritation, and may be useful for prevention of chlamydial infection.

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Citations

Mar 14, 2007·Antimicrobial Agents and Chemotherapy·D L PattonS L Hillier
Sep 25, 2004·Antimicrobial Agents and Chemotherapy·Charlene S DezzuttiClyde E Hart
Feb 7, 2001·Sexually Transmitted Infections·B D ReedD N Wirawan
Jun 3, 2006·BMC Infectious Diseases·Richard A ConeThomas R Moench
Feb 2, 2006·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Gopal Gupta
Jul 5, 2008·The International Journal of Biochemistry & Cell Biology·Dana HuskensDominique Schols
Mar 13, 2015·Pathogens and Disease·Elizabeth NeuendorfJacques Ravel
Oct 17, 1998·Sexually Transmitted Diseases·D L PattonS L Hillier
Jul 19, 2001·Sexually Transmitted Diseases·D L PattonS L Hillier
Oct 9, 2002·Sexually Transmitted Diseases·Dorothy L PattonSharon L Hillier
Nov 20, 2002·Sexually Transmitted Diseases·Sharon L AchillesRichard A Cone
Apr 6, 2004·Journal of Medical Primatology·Dorothy L PattonSharon L Hillier
Apr 27, 2004·Sexually Transmitted Diseases·D L PattonS L Hillier
May 13, 2006·Sexually Transmitted Diseases·Dorothy L PattonSharon L Hillier
Jul 26, 2005·Sexually Transmitted Diseases·Bernard J Moncla, Sharon L Hillier
Jul 3, 2003·Sexually Transmitted Diseases·Dorothy L PattonSharon L Hillier
Apr 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sharon L HillierFulvia Veronese

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