Effects of Nonsteroidal Anti-Inflammatory Drugs at the Molecular Level

The Eurasian Journal of Medicine
Caner Gunaydin, S Sirri Bilge

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for their anti-inflammatory, analgesic, and antipyretic effects. NSAIDs generally work by blocking the production of prostaglandins (PGs) through the inhibition of two cyclooxygenase enzymes. PGs are key factors in many cellular processes, such as gastrointestinal cytoprotection, hemostasis and thrombosis, inflammation, renal hemodynamics, turnover of cartilage, and angiogenesis. Interest has grown in the various effects of NSAIDs during the last decade. Epidemiological studies have revealed the reduced risk of several cancer types and neurodegenerative diseases by prolonged use of NSAIDs. Recent advances in the understanding of the cellular and molecular mechanisms of NSAIDs will accelerate the processes of discovery and clinical implementation. This review summarizes the molecular mechanisms of NSAIDs on the body systems.

Citations

Mar 28, 2019·Journal of Cellular Physiology·Reza Alizadeh, Ziba Aghsaie Fard
Jul 25, 2020·Drug Research·Hugo F MirandaJuan Carlos Prieto
Mar 10, 2020·The Journal of Toxicological Sciences·Sosuke KishiYoko Matsuda
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Oct 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mifta Ahmed JyotiJesus Simal-Gandara
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