PMID: 9548108Apr 21, 1998Paper

Effects of nonsteroidal antiinflammatory medication on satellite cell proliferation during muscle regeneration

The American Journal of Sports Medicine
O ThorssonH Kalimo

Abstract

Previous experimental studies have indicated delayed muscle regeneration after nonsteroidal antiinflammatory drug therapy. Successful regeneration of muscle after injury requires activation of normally dormant satellite cells that share the basal laminae with adjacent muscle cells. In the presence of adequate capillary ingrowth, satellite cells proliferate into myotubes and eventually form new muscle cells. In this study, the onset and extent of satellite cell and fibroblast proliferation as well as the production of myotubes and capillaries were analyzed with immunohistochemical methods after contusion injuries to rats' gastrocnemius muscles. Two groups of animals received daily doses of an intramuscular nonsteroidal antiinflammatory drug (naproxen) starting 6 hours and 3 days after injury, respectively. Treated animals were compared with similarly injured untreated animals. Satellite cell and fibroblast proliferation were unaffected by the treatment, and there were no significant differences in myotube or capillary production between treated and control animals. We conclude that naproxen treatment does not compromise the basic process of myofiber regeneration after injury.

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Citations

Sep 1, 2004·Sports Medicine·Jean-Louis Croisier
Apr 27, 2005·The American Journal of Sports Medicine·Tero A H JärvinenMarkku Järvinen
Feb 18, 2011·Expert Opinion on Emerging Drugs·Stefan M Gehrig, Gordon S Lynch
May 24, 2016·Orthopaedic Journal of Sports Medicine·Tomas F Fernandez-JaénJuan Manuel Lopez Alcorocho
May 1, 2011·Revista Brasileira De Ortopedia·Tiago Lazzaretti FernandesArnaldo José Hernandez
Mar 8, 2019·Journal of Cachexia, Sarcopenia and Muscle·Taimoor H QaziTobias Winkler
Jan 31, 2002·Sports Medicine·Becky Kendall, Roger Eston
Jun 16, 2009·Journal of Muscle Research and Cell Motility·M MondaB De Luca
Mar 28, 2012·Scandinavian Journal of Medicine & Science in Sports·A L MackeyM Kjaer
Jul 2, 2014·Sports Health·Natalie R DannaJoseph A Bosco
Feb 6, 1999·The American Journal of Sports Medicine·J RantanenH Kalimo
Apr 16, 2004·American Journal of Physiology. Cell Physiology·Brenda A BondesenGrace K Pavlath
Apr 28, 2007·Journal of Applied Physiology·Abigail L MackeyHenning Langberg
Dec 11, 1999·Current Opinion in Neurology·M D Grounds
Apr 6, 2000·Current Opinion in Rheumatology·T A JärvinenH Kalimo
Feb 21, 2002·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·John Orchard, Thomas M Best
Aug 16, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·William FosterJohnny Huard
Sep 17, 2004·Muscle & Nerve·Christopher L MendiasRonald E Allen
Dec 2, 2004·The American Journal of Sports Medicine·Frank T G RahusenLouis C Almekinders
Oct 22, 2008·Sports Medicine·Carine SmithKathryn H Myburgh
May 21, 2008·Sports Medicine·Antti AlarantaIlkka Helenius
Oct 14, 2020·Journal of Tissue Engineering and Regenerative Medicine·Stephen M GoldmanChristopher L Dearth

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