PMID: 11345455May 10, 2001Paper

Effects of nonylphenol, bisphenol A, and their mixture on the viviparous swordtail fish (Xiphophorus helleri)

Environmental Toxicology and Chemistry
H I KwakM H Cho

Abstract

A number of fish species have been used for studies on endocrine disrupting chemicals (EDCs). However, despite the widespread use of oviparous fish, relatively little attention has been given to viviparous species. This study investigated the effects of EDCs in a viviparous fish and examined the possible usefulness of the fish as an alternative model for the studies on EDCs. Swordtails (Xiphophorus helleri) were exposed to nonylphenol (NP), bisphenol A (BPA), and their mixture. Both short-term (3-d) and relatively long-term (60-d) exposures were carried out using adult male and 30-d-old juvenile fish, respectively. Following the short-term exposure, both NP and BPA caused vitellogenin mRNA expression. Flow cytometric analysis and terminal deoxynucleotidyl transferase assay on the testes of treated fish indicated reproductive damage. Histopathological analysis found degenerative and necrotic cells in seminiferous tubules following the exposure to 100 ppb NP. The testes with lesions were also associated with highly suppressed spermatogenesis. Following the long-term exposure, both NP and BPA exposures significantly affected the growth of swordtails. In all cases, the results showed that the mixture was always more potent than a s...Continue Reading

Citations

Feb 28, 2004·Life Sciences·Miho AokiToshio Iwakuma
Aug 21, 2003·Ecotoxicology and Environmental Safety·K Van den BeltH Witters
Feb 6, 2008·Zebrafish
Jul 5, 2006·Environmental Health Perspectives·Gwynne Lyons
Feb 15, 2011·Applied and Environmental Microbiology·Rubing LiangJianhua Liu
May 18, 2013·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Martin HulakPavla Linhartova
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Jul 10, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert E ChapinSusan R Woskie
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Nov 6, 2012·Archives of Environmental Contamination and Toxicology·Andrea Cecilia HuedMaría de Los Ángeles Bistoni
Feb 14, 2013·Fish Physiology and Biochemistry·Thea M EdwardsLouis J Guillette

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