Effects of norepinephrine on expression of IGF-1/IGF-1R and SERCA2 in rat heart

Cardiovascular Research
X Sun, Y C Ng

Abstract

The effects of norepinephrine on expression of cardiac genes during pathological cardiac growth and heart failure are not fully understood. Tissue insulin-like growth factor 1 (IGF-1) and its receptor (IGF-1R) play an important role in the regulation of the hyperplastic capacity of cardiac myocytes. Sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2), on the other hand, is important in regulating cardiac contractile function. The present study examined the effects of elevated levels of NE on expression of IGF-1/IGF-1R and SERCA2 mRNAs. Rats were infused with NE using osmotic minipumps for 3 and 6 days at a rate of 50 micrograms/kg/h and also at a higher dose (130 micrograms/kg/h) for 6 and 14 days. Levels of expression of IGF-1/IGF-1R and SERCA2 mRNAs were determined by ribonuclease protection assay and by Northern blotting, respectively. NE treatment significantly increased IGF-1 mRNA levels in both left- and right-ventricle; however, levels of IGF-1R increased in the left- but not the right-ventricle. By contrast, NE infusion at both the lower dose and the higher dose failed to alter expression of SERCA2 mRNA. Our results suggest that NE treatment differentially regulates expression of IGF-1 and IGF-1R in the ventricles of rat hear...Continue Reading

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Citations

Jan 27, 2000·Cytokine & Growth Factor Reviews·B R LackeyD M Henricks
Sep 1, 2014·Cell and Tissue Research·Abbas HajifathaliMahsa Rasekhi
Jul 29, 2003·Journal of Cardiovascular Pharmacology·Shoko MiuraKunio Shirato
Jun 29, 2010·The Journal of Experimental Biology·Tristan C DumbartonFrank M Smith

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