Effects of normal blood pressure, prehypertension, and hypertension on coronary microvascular function

Dogan ErdoganHaldun Muderrisoglu


The assessment of coronary flow reserve (CFR) by transthoracic Doppler echocardiography has recently been introduced into clinical practice, and reduced CFR has been suggested to be a sensitive indicator of hypertensive end-organ damage; however, to date, this methodology has not been used to evaluate CFR in subjects with prehypertension. Accordingly, the present study was designed to evaluate CFR in subjects with prehypertension. We measured CFR of 40 subjects with prehypertension, 60 patients with hypertension, and 50 normotensive healthy volunteers using transthoracic Doppler echocardiography. None of the subjects had any systemic disease. Age, gender, body mass index, heart rate, lipid profiles, fasting glucose levels, and hemoglobin were similar among the 3 groups. CFR was significantly lower in the hypertension group than in the prehypertension and control groups; in addition, it was significantly lower in subjects with prehypertension than in control subjects (2.23+/-0.47, 2.54+/-0.48, and 2.91+/-0.53, respectively). Furthermore, we found that prehypertension (beta=-0.31, P<0.01) and hypertension (beta=-0.57, P<0.01) were significant predictors of lower CFR in a multivariable model that adjusted for other variables. CFR ...Continue Reading


Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Nov 17, 1988·The New England Journal of Medicine·J E BrushS E Epstein
Jul 21, 1998·Journal of the American College of Cardiology·H LaineJ Knuuti
Jun 20, 2001·American Journal of Hypertension·E D Frohlich
Jan 17, 2002·The New England Journal of Medicine·R S VasanD Levy
Oct 10, 2002·The American Journal of Cardiology·Maurizio GalderisiOreste de Divitiis
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eric L KnightGary C Curhan
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Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Dec 14, 2004·The American Journal of Cardiology·Arch G MainousBrent M Egan
Mar 23, 2005·Hypertension·Francesca ViazziRoberto Pontremoli
Aug 2, 2005·American Journal of Hypertension·Shawna D NesbittUNKNOWN TROPHY Study Investigators
Aug 6, 2005·Stroke; a Journal of Cerebral Circulation·Adnan I QureshiYousef Mohammad
Jan 3, 2006·Heart·D ErdoganH Muderrisoglu
Feb 7, 2006·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Roberto M LangUNKNOWN European Association of Echocardiography, European Society of Cardiology
Mar 8, 2006·Hypertension·Jung Eun LeeHa Young Oh

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