Effects of NREM sleep on dynamic within-breath changes in upper airway patency in humans

Journal of Applied Physiology
M J Morrell, M S Badr

Abstract

The purpose of our study was to compare inspiratory- and expiratory-related changes in retropalatal cross-sectional area (CSA) during wakefulness to those during non-rapid-eye-movement (NREM) sleep. We studied 18 subjects in whom the severity of sleep-disordered breathing varied. Relative changes in CSA were visualized by using fiber-optic endoscopy. For each breath analyzed (wakefulness n = 4-13; sleep n = 7-16), the CSA was measured at fixed points within inspiration and expiration (0, 25, 50, and 100% of the inspiratory and expiratory duration); these measurements were expressed as a percentage of the CSA that occurred at the start of inspiration. During wakefulness, there was a statistically significant increase in the retropalatal CSA (compared with the start of inspiration) only during early expiration (group mean: expiration, 0% = 112.6 +/- 3.2 (SE) %; 25% = 122.8 +/- 6.2%; 50% = 110.6 +/- 3.8%). In contrast, during sleep, significant changes in CSA occurred during both inspiration and expiration (group mean: inspiration, 25% = 75.3 +/- 6.0%; 50% = 66.7 +/- 7.7%; 75% = 64.6 +/- 8.1%; expiration, 0% = 126.8 +/- 11.8%; 25% = 125.3 +/- 6.9%). The expiratory-related increase in CSA was followed by narrowing such that at end ...Continue Reading

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Citations

Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·M J MorrellM S Badr
Apr 17, 2002·American Journal of Respiratory and Critical Care Medicine·Eve L BijaouiJason H T Bates
Jan 28, 2006·American Journal of Respiratory and Critical Care Medicine·Michael J BrennickSamuel T Kuna
Feb 10, 2009·American Journal of Respiratory and Critical Care Medicine·Abdul Ghani Sankri-TarbichiM Safwan Badr
May 26, 2012·Journal of Applied Physiology·Robert L OwensAndrew Wellman
Jan 25, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ning-Hung ChenCheng-Ta Yang
Oct 22, 2005·American Journal of Respiratory and Critical Care Medicine·Julian J ArmstrongPeter R Eastwood
Oct 23, 2002·Journal of Applied Physiology·Mark BabcockM Safwan Badr
Oct 12, 2019·The European Respiratory Journal·Peter R EastwoodSandrine H Launois
Jun 16, 2001·Journal of Applied Physiology·J A RowleyM S Badr
May 17, 2002·Journal of Applied Physiology·James A RowleyM Safwan Badr
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Feb 24, 2015·Current Neurology and Neuroscience Reports·Julian P SaboiskySimon C Gandevia
Jan 31, 2015·Journal of Applied Physiology·Kristina KairaitisTerence C Amis
Sep 10, 2005·Journal of Applied Physiology·Khaled F MansourM Safwan Badr
Sep 20, 2021·Archives of Physical Medicine and Rehabilitation·Gino S PanzaUNKNOWN American Congress of Rehabilitation Medicine, Interdisciplinary Special Interest Group, Spinal Cord Injury Physical Function

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