Effects of nucleoside transport inhibition on hepatosplanchnic perfusion, oxygen extraction capabilities, and TNF release during acute endotoxic shock

Shock
H ZhangJ L Vincent

Abstract

We explored the effects of the nucleoside transport inhibitor draflazine on regional blood flow, O2 extraction capabilities, and tumor necrosis factor (TNF) release in acute endotoxic shock. Fourteen anesthetized and mechanically ventilated dogs received 2 mg/kg of Escherichia coli endotoxin and were divided into two groups. Seven dogs received 0.1 mg/kg of draflazine 30 min before endotoxin, and 7 dogs served as a control group. Draflazine decreased arterial pressure without influencing cardiac index. Mesenteric and portal blood flow and ileum mucosal perfusion increased, but renal blood flow dramatically decreased. After endotoxemia, the draflazine-treated dogs had a lesser fall in cardiac index, filling pressures, and left ventricular stroke work index, and a lesser increase in pulmonary vascular resistance. After fluid resuscitation, they had a consistently lower renal blood flow and ileum mucosal perfusion, but a higher mixed venous and hepatic oxygen saturation and arterial pH than the control group. When cardiac index was reduced by tamponade to study the O2 extraction capabilities, renal blood flow and ileum mucosal perfusion remained lower in the draflazine group. Draflazine did not influence whole-body O2 extraction c...Continue Reading

Citations

Mar 27, 2003·Current Opinion in Critical Care·Eugene P CeppaGregory B Bulkley
Sep 3, 2005·Critical Care : the Official Journal of the Critical Care Forum·Christoph LangenbergStanislao Morgera
Feb 22, 2005·Journal of Veterinary Pharmacology and Therapeutics·S Sentürk
Jul 10, 2007·The Journal of Small Animal Practice·Z Yilmaz, S Senturk
May 13, 2006·Nephron. Physiology·Christoph LangenbergStanislao Morgera
Nov 20, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zheng F BaIrshad H Chaudry

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