Effects of nut consumption on selected inflammatory markers: a systematic review and meta-analysis of randomized controlled trials

Nutrition
Yunjun XiaoXuefen Su

Abstract

Several randomized controlled trials (RCTs) have assessed the effects of nut consumption on inflammatory markers. However, the results have been inconsistent. The aim of this meta-analysis of RCTs was to quantitatively evaluate the effects of nut consumption on selected inflammatory markers. PubMed, Embase, Cochrane Library database, and Google Scholar were searched for published RCTs that reported the effects of nuts on inflammatory markers as primary or secondary outcomes in an adult population (aged ≥18 y). Summary estimates of weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated using random-effects meta-analysis. Twenty-three RCTs met the inclusion criteria. Overall, nut consumption significantly reduced the levels of intercellular adhesion molecule (ICAM)-1 (WMD, -0.17; 95% CI, -0.32 to -0.03; P = 0.01), but had no significant effect on other inflammatory markers. In the subgroup analyses by nut types, mixed nuts had a significant effect on ICAM-1 reduction. The significant effect of nuts on ICAM-1 reduction was only observed in parallel, but not crossover RCTs. Additionally, nut consumption significantly reduced ICAM-1 and vascular cell adhesion molecule-1 levels in long-term (≥12 wk), but ...Continue Reading

Citations

Jul 31, 2019·Phytotherapy Research : PTR·Alessandra DurazzoAntonello Santini
Jan 15, 2020·European Cardiology·Amelia Carro, Josefa María Panisello
Dec 14, 2018·International Journal of Molecular Sciences·Rosa CasasEmilio Sacanella
Dec 20, 2018·Nutrients·Yoona KimPeter M Clifton
Dec 11, 2020·International Journal of Environmental Research and Public Health·Elizabeth P NealeRachel C Brown
Mar 7, 2021·International Journal of Environmental Research and Public Health·Agnieszka MicekGiuseppe Grosso

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