Effects of nutraceutical intervention on serum proteins in aged rats.

GeroScience
Samantha M PortisPaula C Bickford

Abstract

Aging is associated with many pathophysiological changes that could lead to the onset of degenerative disease. Some of the physiological changes that occur with aging include increased inflammation and decreased stem cell proliferation, leading to decreased capacity for tissue regeneration and loss of function. In previous studies, we and others have found nutraceutical intervention to ameliorate some of the deleterious effects associated with aging. In particular, we have previously shown that NT-020, a supplement composed of a proprietary blend of blueberries, green tea, vitamin D3, and carnosine, is able to rescue age-related cognitive deficits, impaired neurogenesis, and inflammation in rats. We have also previously demonstrated that stem cells cultured with old serum showed decreased proliferation; however, when stem cells were cultured in serum from old rats given a diet supplemented with NT-020, proliferation did not differ from that of cells cultured with serum from young rats. While it is clear that NT-020 is exerting a therapeutic, anti-aging effect, the mechanisms of action were yet to be fully elucidated.To that end, in the present study, we conducted a bioinformatics experiment to examine the rat proteome of serum ...Continue Reading

References

Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kavon Rezai-ZadehJun Tan
Mar 9, 2006·Stem Cells and Development·Paula C BickfordPaul R Sanberg
Aug 22, 2006·Biochemical Pharmacology·Irfan RahmanPaul A Kirkham
Sep 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suh Young Jeong, Samuel David
Aug 7, 2007·PLoS Biology·Stuart M ChambersMargaret A Goodell
Aug 25, 2007·Nature Reviews. Molecular Cell Biology·Norman E Sharpless, Ronald A DePinho
Feb 12, 2008·Rejuvenation Research·Takao YasuharaCesar V Borlongan
Apr 16, 2008·Journal of Cellular and Molecular Medicine·Kavon Rezai-ZadehJun Tan
Nov 18, 2009·Journal of Neuroinflammation·Julia ReichwaldMatthias Staufenbiel
Dec 17, 2009·The Journal of Biological Chemistry·J Christopher FrittonShoshana Yakar
Oct 22, 2010·Trends in Neurosciences·Orly LazarovHenriette van Praag
Jul 10, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Molly V WagsterPeter R Rapp
Jul 28, 2012·International Journal of Molecular Sciences·Yuji KanekoCesar V Borlongan
Jun 8, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Ayesha MurshidStuart K Calderwood
Oct 19, 2013·Rejuvenation Research·Brent J SmallPaula C Bickford
Dec 4, 2014·Cytokine & Growth Factor Reviews·Jieyi LiDietbert Neumann
Apr 29, 2015·Advances in Experimental Medicine and Biology·Nuria Martinez-LopezRajat Singh
Sep 18, 2015·Journal of Neuroinflammation·Antwoine FlowersPaula C Bickford
Dec 15, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Paola Lucia MinciulloGiorgio Basile
Jun 28, 2016·Nature Methods·Stefka TyanovaJürgen Cox
Sep 7, 2016·Journal of Neuroinflammation·Antwoine FlowersPaula C Bickford
Sep 30, 2016·PloS One·Jieyi LiRonit Shiri-Sverdlov
Feb 24, 2017·Immunity·Bertrand CalippeFlorian Sennlaub
Aug 8, 2017·Aging Cell·Miren Revuelta, Ander Matheu
Mar 3, 2018·Frontiers in Aging Neuroscience·Ryo MukaiKip M Connor
May 26, 2018·International Psychogeriatrics·Cheolmin ShinChangsu Han
Aug 18, 2018·Nature Reviews. Drug Discovery·Barry BolandMark J Millan
Oct 3, 2018·International Archives of Allergy and Immunology·Nihal Mete GökmenAytül Zerrin Sin

❮ Previous
Next ❯

Citations

Jun 3, 2021·Biomedicines·Isaac G OnyangoGorazd B Stokin

❮ Previous
Next ❯

Methods Mentioned

BETA
serum collection
peptide collection
acetylation

Software Mentioned

Ingenuity Pathway Analysis ( IPA
IPA
Excel
Perseus
MaxQuant

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms