PMID: 11930091Apr 4, 2002Paper

Effects of nutritional rehabilitation on intestinal function and on CD4 cell number in children with HIV

Journal of Pediatric Gastroenterology and Nutrition
Alfredo GuarinoGuido Castelli Gattinara

Abstract

A complex interplay of malnutrition, intestinal dysfunction, and immune impairment increases the progression of human immunodeficiency virus (HIV) disease in children. The authors tested the hypothesis that nutritional support improves intestinal and immune functions in children infected with human immunodeficiency virus (HIV). A questionnaire was circulated through reference centers for pediatric HIV infection to evaluate the effects of nutritional rehabilitation, total parenteral nutrition (TPN) and enteral nutrition (EN), in children. Information included changes in body weight, CD4 cell numbers, and intestinal absorption-as judged by the xylose load-before and after clinical nutritional support and the outcome of children. Sixty-two children underwent nutritional support: 46 received TPN and 16 received EN. All but three had full-blown acquired immunodeficiency syndrome, and all were severely malnourished. Baseline clinical conditions were worse in children receiving TPN than in those receiving EN. Intestinal dysfunction was detected in all children who received xylose oral load. A significant increase in CD4 cell count, xylose levels, and body weight followed EN. A similar pattern was observed after TPN, but none of the pa...Continue Reading

References

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Citations

Jun 9, 2005·The Journal of Allergy and Clinical Immunology·Susanna Cunningham-RundlesAeri Moon
Jun 9, 2004·Journal of Pediatric Gastroenterology and Nutrition·Dankwart WittenbergUNKNOWN Commonwealth Association of Paediatric Gastroenterology and Nutrition
Dec 23, 2004·Paediatric Drugs·Alfredo GuarinoVittoria Buccigrossi
May 18, 2006·Nutrition·Joel FaintuchHelio G Osmo
Feb 27, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Beth Wallace
Jul 31, 2008·Journal of Pediatric Gastroenterology and Nutrition·Tracie L MillerUNKNOWN HIV Working Group
Apr 4, 2002·Journal of Pediatric Gastroenterology and Nutrition·Tracie L Miller

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