Effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism in children with chronic kidney disease

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Christian LerchESPN CKD-MBD working group

Abstract

We investigated the effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism, i.e. serum levels of fibroblast growth factor 23 (FGF23), Klotho, bone alkaline phosphatase (BAP) and sclerostin, in two cohorts with chronic kidney disease (CKD). In all, 80 vitamin D-deficient children were selected: 40 with mild to moderate CKD from the ERGO study, a randomized trial of ergocalciferol supplementation [estimated glomerular filtration rate (eGFR) 55 mL/min/1.73 m2], and 40 with advanced CKD from the observational Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study (eGFR 24 mL/min/1.73 m2). In each study, vitamin D supplementation was started in 20 children and 20 matched children not receiving vitamin D served as controls. Measures were taken at baseline and after a median period of 8 months. Age- and gender-related standard deviation scores (SDSs) were calculated. Before vitamin D supplementation, children in the ERGO study had normal FGF23 (median 0.31 SDS) and BAP (-0.10 SDS) but decreased Klotho and sclerostin (-0.77 and -1.04 SDS, respectively), whereas 4C patients had increased FGF23 (3.87 SDS), BAP (0.78 SDS) and sclerostin (0.76 SDS) but normal Klotho (-0.27 SDS) lev...Continue Reading

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Citations

Oct 31, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gurpreet KaurJuhi Kumar
May 16, 2020·The Journal of Clinical Endocrinology and Metabolism·Annika EwertDieter Haffner
Sep 6, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carmine ZoccaliChristoph Wanner
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Jan 20, 2021·Current Opinion in Nephrology and Hypertension·Anne M Kouri, Michelle N Rheault
Feb 4, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasiliki KaravaNikoleta Printza
Mar 7, 2021·Medicina·Guido GembilloDomenico Santoro
Dec 29, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Arpana IyengarRukshana Shroff
Mar 28, 2021·European Journal of Clinical Nutrition·Fatemeh MeshkiniShima Abdollahi
Aug 28, 2021·British Journal of Clinical Pharmacology·Mandy WanJignesh P Patel

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