Effects of obesity and hormone therapy on surgically-confirmed fibroids in postmenopausal women

European Journal of Epidemiology
Eva M SommerMillion Women Study Collaborators

Abstract

To examine the association between body mass index (BMI), use of menopausal hormone therapy (HT), and incidence of uterine fibroids in postmenopausal women, 610,604 postmenopausal women without prior hysterectomy or diagnosis of fibroids were followed as part of a large United Kingdom prospective cohort study. We used Cox regression models to calculate adjusted relative risks (RRs) of surgically-confirmed fibroids (defined as a hospital admission with uterine fibroids as a primary diagnosis with a related surgical procedure), in relation to BMI and use of HT. During an average of 11.4 years of follow-up, 3561 women were admitted to hospital with surgically-confirmed fibroids. Five-year incidence rates decreased with age, from 0.50% (1 in 200 women) at age 50-54, to 0.11% (1 in 1000 women) at age 75-79. The 5-year rate in postmenopausal women aged 50-54 was about a quarter that seen in premenopausal women of the same age (1 in 200 vs. 1 in 50). Compared with normal weight women, obese women had a RR of surgically-detected fibroids of 1.46 (95% CI 1.33-1.59; p < 0.0001). HT use was associated with a RR of 2.33 (95% CI 2.18-2.49; p < 0.0001) in ever versus never users. When we analysed HT use and BMI together, obese vs. normal wei...Continue Reading

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Citations

Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dana DvorskáJozef Višňovský
Apr 8, 2018·Current Medical Research and Opinion·Ji-Eun LeeJung Eun Lee
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Dec 24, 2015·Menopause : the Journal of the North American Menopause Society·Rogerio A Lobo
May 16, 2020·Scientific Reports·Jin-Woo LeeKyung Sook Kim
Aug 26, 2021·Human Reproduction Update·Andrea R GenazzaniTommaso Simoncini
Sep 2, 2021·Menopause : the Journal of the North American Menopause Society·Minghong ShenSha Wang
Sep 15, 2021·Menopause : the Journal of the North American Menopause Society·Juana Hutchinson-Colas

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Methods Mentioned

BETA
hysterectomy
hysterectomies
bilateral oophorectomy

Software Mentioned

Stata

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