PMID: 8593753Jul 1, 1995Paper

Effects of obesity and inheritance on the development of non-insulin-dependent diabetes mellitus in Otsuka-Long-Evans-Tokushima fatty rats

Diabetes Research and Clinical Practice
N OkauchiK Shima

Abstract

We studied whether obesity or inheritance was the more important factor in the development of non-insulin-dependent diabetes mellitus (NIDDM) using female Otsuka-Long-Evans-Tokushima Fatty rats (OLETF) possessing one of the diabetic genes, ODB-1, and male Long-Evans-Tokushima-Otsuka rats (LETO) possessing no ODB-1, neither of which were diabetic when bred normally. Diabetes-resistant male LETO rats and female OLETF rats (4 weeks old) were assigned to three groups of 6 rats each, respectively; two groups in which obesity was induced by high calorie 'cafeteria' diet (D), or ventromedial hypothalamus lesions (V) with normal chow diet and a control group fed on normal chow (C). Six male OLETF rats were used as NIDDM positive controls. The mean daily energy intakes of obese male LETO and female OLETF rats were higher than those of the respective C groups. At 27 weeks of age, the average body weights of the obese LETO and female OLETF rats were significantly higher than those of the respective C groups and similar to that of the male OLETF group. Abdominal fat deposits of the obese groups were significantly higher than those of the respective C groups. At 28 weeks of age, the cumulative incidence of diabetes mellitus in obese LETO ra...Continue Reading

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Citations

Apr 1, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Zhimin MiaoCong-Yi Wang
Mar 27, 2004·Metabolism: Clinical and Experimental·Dongmei JiaMakoto Otsuki
Nov 9, 2000·Clinical and Experimental Pharmacology & Physiology·Y YamasakiA Tanigami
Dec 6, 2000·Journal of Gastroenterology and Hepatology·D M JiaM Otsuki
Jul 20, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Min ZhuSige Zou
Aug 28, 2010·Nutrition Research·Yukihito IshiiMutsuyoshi Matsushita
Jan 18, 2006·Diabetes Research and Clinical Practice·Myeung-Ju KimKee-Wook Jung
Nov 3, 2012·Experimental Diabetes Research·Takahisa YamadaKozo Matsumoto
Nov 29, 2016·The Journal of Veterinary Medical Science·Mei YoshidaAkihiko Maeda
Feb 19, 2014·International Journal of Toxicology·Kuk-Young MoonAn-Soo Jang
Oct 1, 1996·Metabolism: Clinical and Experimental·K IshidaK Shima

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