Effects of obesity and weight loss on the functional properties of early outgrowth endothelial progenitor cells

Journal of the American College of Cardiology
Nana-Maria HeidaKatrin Schäfer

Abstract

The purpose of this study was to examine the impact of obesity and weight loss on the angiogenic and regenerative capacity of endothelial progenitor cells (EPCs). EPCs participate in angiogenesis and tissue repair. Several cardiovascular risk factors are associated with EPC dysfunction. Early outgrowth EPCs were isolated from 49 obese (age 42 +/- 14 years; body mass index 42 +/- 7 kg/m(2)) normoglycemic participants in a professional weight reduction program and compared with those from 49 age-matched lean controls. EPC function was tested both in vitro and in vivo. EPCs expanded from the obese possessed reduced adhesive, migratory, and angiogenic capacity, and mice treated with obese EPCs exhibited reduced EPC homing in ischemic hind limbs in vivo. EPCs from the obese subjects failed to respond to conditioned medium of lean controls or to potent angiogenic factors such as vascular endothelial growth factor. Although no differences existed between lean and obese EPCs regarding the surface expression of vascular endothelial growth factor or chemokine receptors, basal p38 mitogen-activated protein kinase (MAPK) phosphorylation was elevated in obese EPCs (3.7 +/- 2.1-fold increase; p = 0.006). These cells also showed reduced secre...Continue Reading

References

Jun 15, 2004·Journal of the American College of Cardiology·Jalees RehmanKeith L March
Dec 2, 2004·Journal of Molecular and Cellular Cardiology·Moon Y LimLinda S Higgins
Mar 9, 2005·Circulation·Florian H SeegerStefanie Dimmeler
Apr 20, 2005·Circulation·Andrea E CassidyPatricia A Peyser
May 14, 2005·Circulation Research·Anders H Berg, Philipp E Scherer
Sep 9, 2005·The New England Journal of Medicine·Nikos WernerGeorg Nickenig
Oct 4, 2005·Journal of Molecular and Cellular Cardiology·Carmen UrbichStefanie Dimmeler
Mar 30, 2007·Leukemia·D N PraterM C Yoder
Jun 3, 2008·European Heart Journal·Jochen Müller-EhmsenMarkus Flesch

❮ Previous
Next ❯

Citations

Dec 18, 2012·Journal of Thrombosis and Thrombolysis·Guohou HeYanjun Zeng
Feb 22, 2012·Circulation Research·Gian Paolo FadiniStefanie Dimmeler
Jun 14, 2013·Journal of Translational Medicine·Thomas E IchimAmit N Patel
May 16, 2012·BMC Veterinary Research·Chunyu BaiYuehui Ma
Aug 28, 2010·Environmental Health Perspectives·Layla AitlhadjStephen Richard Stürzenbaum
Dec 29, 2012·World Journal of Cardiology·Matina KoutroumpiSerafim Nanas
Aug 19, 2011·International Journal of Medical Sciences·Nina A MikirovaMargaret M Beezley
May 9, 2014·International Journal of Cardiology·Luc BruyndonckxViviane M Conraads
May 22, 2013·Oxidative Medicine and Cellular Longevity·Luc BruyndonckxViviane M Conraads
Jan 24, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·Regina GerterNicolai Miosge
Oct 18, 2014·Journal of the American College of Cardiology·Lina Badimon, Gemma Vilahur
Apr 3, 2012·European Journal of Clinical Investigation·Francesca CesariAlessandro Casini
Sep 1, 2015·Pharmacological Reports : PR·Neli Kachamakova-TrojanowskaAlicja Jozkowicz
Apr 5, 2012·Experimental Diabetes Research·Alessandra PetrelliPaolo Fiorina
Nov 26, 2010·International Journal of Cardiology·Miriam PulsKatrin Schäfer
Apr 27, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E Salazar-MartinezE Lazcano-Ponce
May 17, 2011·PloS One·Virginia Llopis-HernándezManuel Salmerón-Sánchez
Apr 27, 2011·Expert Review of Cardiovascular Therapy·Amir Aziz, Stephen Wheatcroft
May 21, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Roberto TestaAntonio Ceriello
Jan 1, 2020·European Heart Journal·Gian Paolo FadiniArshed Ali Quyyumi
Jul 10, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Blanca OñateLina Badimon
Dec 6, 2011·Molecular and Cellular Biochemistry·Xiaoran Liu, Canmao Xie
Dec 14, 2011·Journal of Cardiovascular Pharmacology·Shengjie XuGuosheng Fu
Oct 20, 2018·Obesity Science & Practice·S T RashidS B Wheatcroft
Feb 28, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Francesca GrazianiFilippo Crea
Mar 6, 2015·The Journal of Bone and Joint Surgery. American Volume·Maria-Victoria NociJulia Carracedo
Oct 31, 2020·International Journal of Sports Medicine·William S EvansSteven J Prior
Apr 16, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Anurag MehtaArshed A Quyyumi
Jun 22, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jesús M PradilloIgnacio Lizasoain
Jul 3, 2021·International Journal of Molecular Sciences·Anne-Christine PeyterCatherine Yzydorczyk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.