Effects of obstructive sleep apnoea risk on postoperative respiratory complications: protocol for a hospital-based registry study

BMJ Open
Christina H ShinMatthias Eikermann

Abstract

Obstructive sleep apnoea (OSA), the most common type of sleep-disordered breathing, is associated with significant immediate and long-term morbidity, including fragmented sleep and impaired daytime functioning, as well as more severe consequences, such as hypertension, impaired cognitive function and reduced quality of life. Perioperatively, OSA occurs frequently as a consequence of pre-existing vulnerability, surgery and drug effects. The impact of OSA on postoperative respiratory complications (PRCs) needs to be better characterised. As OSA is associated with significant comorbidities, such as obesity, pulmonary hypertension, myocardial infarction and stroke, it is unclear whether OSA or its comorbidities are the mechanism of PRCs. This project aims to (1) develop a novel prediction score identifying surgical patients at high risk of OSA, (2) evaluate the association of OSA risk on PRCs and (3) evaluate if pharmacological agents used during surgery modify this association. Retrospective cohort study using hospital-based electronic patient data and perioperative data on medications administered and vital signs. We will use data from Partners Healthcare clinical databases, Boston, Massachusetts. First, a prediction model for OS...Continue Reading

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Citations

Mar 20, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Douglas A DensonJoshua E Everts
Apr 14, 2016·International Journal of Obstetric Anesthesia·Suzanne Karan, Yehuda Ginosar
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Mar 17, 2021·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mandeep SinghRichard Brull

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