Effects of octreotide on acute necrotizing pancreatitis in rabbits

World Journal of Gastroenterology : WJG
L CzakóJ Lonovics

Abstract

To assess the role of oxygen-derived free radicals and cytokines in the pathogenesis of taurocholic acid-induced acute pancreatitis, and to evaluate the preventive effects of octreotide towards the development of acute pancreatitis. Acute pancreatitis was induced in male New Zealand white rabbits by retrograde injection of 0.8 mL/kg.b.m. of 50 g/L sodium taurocholate (NaTC) in the pancreatic duct. Sham-operated animals served as control. Octreotide 1 mg/kg.b.m. was administered subcutaneously before the induction of pancreatitis. Blood was taken from the jugular vein before and at 1, 3, 6, 12 and 24 h after pancreatitis induction. Serum activities of amylase, IL-6 and TNF-alpha and levels of malonyl dialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), catalase and superoxide dismutase (Mn-, Cu-, and Zn-SOD) in pancreatic tissue were measured. Serum TNF-alpha and IL-6 levels increased significantly 3 h after the onset of pancreatitis, and then returned to control level. The tissue concentration of MDA was significantly elevated at 24 h, while the GSH level and GP-x, catalase, Mn-SOD, Cu-, Zn-SOD activities were all significantly decreased in animals with pancreatitis as compared to the control. Octreotide pretreatm...Continue Reading

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Citations

Oct 10, 2014·Mediators of Inflammation·Halina MilnerowiczUtanisław Milnerowicz
Jun 28, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Ahmet GülçubukOzlem Güzel
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Jun 6, 2007·Digestive Diseases and Sciences·Xi Ping ZhangQi Hui Cheng
Oct 8, 2008·Antioxidants & Redox Signaling·Po Sing Leung, Yuk Cheung Chan
Apr 18, 2009·European Journal of Gastroenterology & Hepatology·Dimitrios KapetanosEpaminondas Tsianos
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Nov 26, 2008·World Journal of Gastroenterology : WJG·Xi-Ping ZhangWen-Qin Yuan
Jan 1, 2012·World Journal of Emergency Medicine·Ying-Zhen WangZhi-Jiang Sun

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