PMID: 1201381Oct 1, 1975Paper

Effects of oestradiol and progesterone on the in vitro production of prostaglandin F2alpha by the guinea-pig uterus

British Journal of Pharmacology
B Naylor, N L Poyser

Abstract

1 The effects of oestradiol and progesterone on the production of F 2alpha by the guinea-pig uterus in vitro have been studied. 2 Ovariectomized guinea-pigs were treated with oestradiol benzoate, progesterone, or a combination of these hormones. The uteri were homogenized and incubated and the prostaglandin F2alpha produced was measured by radiommunoassay or combined gas chromatography-mass spectrometry (g.c.-m.s.). Oestradiol treatment or progesterone followed by oestradiol caused a significant increase in prostaglandin F2alpha synthesis compared with control values, whereas progesterone treatment caused no significant increase. 3 The uteri from guinea-pigs on day 7 of the oestrous cycle were split into four parts, and each part homogenized and incubated either alone or in the presence of oestradiol-17beta, progesterone, or a combination of these hormones. Prostaglandin F2alpha was measured by g.c.-m.s. Oestradiol was found to increase prostaglandin F2alpha synthesis by the uterus whereas progesterone had no effect. However, progesterone did inhibit the response to oestradiol. 4 Oestradiol treatment of the guinea-pig uterus causes an increase in capacity to produce prostaglandin F2alpha in vitro. The role of progesterone is di...Continue Reading

References

Feb 1, 1975·Prostaglandins·E M Cane, C A Villee
Jul 1, 1972·The Journal of Endocrinology·N L Poyser
Jun 1, 1970·The Journal of Endocrinology·K P Bland, B T Donovan
Aug 1, 1968·Journal of Reproduction and Fertility·J B Choudary, G S Greenwald
Jan 1, 1967·Journal of Animal Science·C O WoodyA L Pope

❮ Previous
Next ❯

Citations

Jul 1, 1988·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R NemmeE Papiernik
Oct 1, 1976·Prostaglandins·G Valenzuela, M J Harper
Oct 1, 1980·Prostaglandins·R W Kelly, M H Abel
Dec 1, 1983·Prostaglandins·P L PakrasiS K Dey
Oct 1, 1987·Prostaglandins·G E RiceG D Thorburn
Jan 1, 1984·Pharmacology & Therapeutics·B J Furr, V C Jordan
Nov 1, 1982·Prostaglandins, Leukotrienes, and Medicine·F D Lytton, N L Poyser
Aug 1, 1979·British Journal of Obstetrics and Gynaecology·O YlikorkalaA Kauppila
Apr 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A M FranchiM A Gimeno
Feb 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A M FranchiA L Gimeno
Sep 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P Peplow, J Y Jeremy
Jul 1, 1985·British Journal of Obstetrics and Gynaecology·M C HanssensE M Symonds
Jan 9, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·R RomeroM Mazor
Aug 1, 1976·The Journal of Pharmacy and Pharmacology·S E Robinson, F Sulser
Sep 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N L Poyser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.