Effects of oestradiol on LH, FSH and prolactin in ovariectomized ewes

Journal of Reproduction and Fertility
T G Rozell, D H Keisler

Abstract

This study was conducted to test the hypothesis that the rate (dose/time) at which oestradiol-17 beta (oestradiol) is presented to the hypothalamo-pituitary axis influences secretion of LH, FSH and prolactin. A computer-controlled infusion system was used to produce linearly increasing serum concentrations of oestradiol in ovariectomized ewes over a period of 60 h. Serum samples were collected from ewes every 2 h from 8 h before to 92 h after start of infusion, and assayed for oestradiol, LH, FSH and prolactin. Rates of oestradiol increase were categorized into high (0.61-1.78 pg/h), medium (0.13-0.60 pg/h) and low (0.01-0.12 pg/h). Ewes receiving high rates of oestradiol (N = 11) responded with a surge of LH 12.7 +/- 2.0 h after oestradiol began to increase, whereas ewes receiving medium (N = 15) and low (N = 11) rates of oestradiol responded with a surge of LH at 19.4 +/- 1.7 and 30.9 +/- 2.0 h, respectively. None of the surges of LH was accompanied by a surge of FSH. Serum concentrations of FSH decreased and prolactin increased in ewes receiving high and medium rates of oestradiol, when compared to saline-infused ewes (N = 8; P less than 0.05). We conclude that rate of increase in serum concentrations of oestradiol controls ...Continue Reading

Citations

Apr 1, 1993·Domestic Animal Endocrinology·R J MoffattD H Keisler
Jan 1, 1996·Domestic Animal Endocrinology·S K JohnsonP E Lewis
Jan 1, 1995·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·X Qin, H Klandorf
Aug 11, 2004·Animal Reproduction Science·Melanie J StarbuckE Keith Inskeep
May 26, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Muraly PuttabyatappaVasantha Padmanabhan
Sep 19, 2016·Domestic Animal Endocrinology·P M BartlewskiD H Keisler
May 1, 1997·Journal of Dairy Science·H A Garverick

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