PMID: 7528021Aug 1, 1994Paper

Effects of oestrogen on rat uterine expression of insulin-like growth factor-binding proteins

Journal of Molecular Endocrinology
P Molnar, L C Murphy

Abstract

Previous studies have established that the IGFs are involved in oestrogen-induced uterine proliferation. IGF-binding proteins (IGFBPs) are present in most biological fluids and tissues and may modulate the actions of the IGFs. We examined uterine, hepatic and renal expression of the IGFBPs throughout the oestrous cycle and investigated the effects of oestradiol (OE2) on IGFBP expression in ovariectomized (ovx) rats. Uterine expression of IGFBPs-1 and -3 showed a definite variation throughout the oestrous cycle with highest levels during dioestrus. In the liver and kidney the changes in IGFBP-1 and IGFBP-3 mRNA abundance were the opposite of those observed in the uterus, with the highest levels observed during oestrus. Administration of OE2 to ovx rats decreased uterine IGFBP-3 mRNA and increased IGFBP-4 mRNA levels. In these rats there were no consistent changes in renal IGFBP-1 or IGFBP-3 mRNAs; however, a significant increase in IGFBP-4 mRNA was observed in this tissue, as in the uterus. In the liver an increase in IGFBP-1 mRNA and a decrease in IGFBP-3 mRNA levels were observed in rats treated with OE2. Despite changes in uterine, hepatic and renal IGFBP mRNA levels, no significant variation was seen in serum IGFBPs as deter...Continue Reading

Citations

Oct 14, 2008·Genes & Nutrition·S Starcke, G Vollmer
Nov 24, 2004·Cell and Tissue Research·C Adriana Mendoza-RodríguezMarco Cerbón
Jul 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·L Sahlin, H Eriksson
Oct 19, 2002·Progress in Neurobiology·Roberto C MelcangiMariarita Galbiati
Jan 1, 1997·Brain Research Bulletin·M C Fernandez-GalazL M Garcia-Segura
Feb 18, 2003·Molecular Reproduction and Development·C Adriana Mendoza-RodríguezMarco Cerbón
Feb 23, 2005·The Journal of Reproduction and Development·Ayako InoueSumio Takahashi
Jan 5, 2006·American Journal of Physiology. Endocrinology and Metabolism·Thomas MünzerMarc R Blackman
Apr 24, 2013·Reproduction, Fertility, and Development·Lisa M CostelloDermot G Morris
Apr 5, 2000·The Journal of Biological Chemistry·D A ZajchowskiG M Rubanyi
Apr 28, 2005·Experimental Biology and Medicine·Shabrine S Daftary, Andrea C Gore
Oct 6, 2018·Environmental Health and Toxicology·Byeonghak MoonSeung Min Oh

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