PMID: 8601579Jan 1, 1996Paper

Effects of okadaic acid on cell growth, anchorage-independent growth, and co-cultures of normal (KMS-6), immortalized (KMST-6), and neoplastically transformed (KMST-6T and KMST-6/RAS) human fibroblasts

Journal of Cancer Research and Clinical Oncology
I JahanM Namba

Abstract

The effects of okadaic acid (OA) on normal human (KMS-6), its immortalized (KMST-6) and neoplastically transformed (KMST-6T and KMST-6/RAS) cells were investigated as a model of two stage carcinogenesis. The presence of OA inhibited cell growth of the normal and immortalized cells but not that of the neoplastic KMST-6T cells. In contrast, cell growth of the other neoplastic KMST-6/RAS cells transformed with the Ha-ras oncogene was inhibited by OA. OA enhanced colony formation of KMST-6T cells in soft agar, but it suppressed that of KMST-6/RAS cells. Co-cultures of KMST-6T cells with normal KMS-6 cells showed an increase in focus formation of KMST-6T cells in the presence of OA, whereas focus formation of KMST-6/RAS cells decreased. These results indicate that OA has growth-promoting effects on certain types of transformed human cells.

References

Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·K MiharaM Namba
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R SakaiM Nagao
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M SuganumaT Sugimura
Oct 15, 1993·Biochemical and Biophysical Research Communications·R W GuptaD A Foster

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Citations

Nov 24, 1999·Journal of Cellular Physiology·S Villalobos Campos, A H Schönthal
Jul 4, 2007·Medical Hypotheses·Emilia ManerioJuan Martinez Hernandez

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