Effects of OKY-046 and nifedipine in cyclosporine-induced renal dysfunction in rats

Prostaglandins, Leukotrienes, and Essential Fatty Acids
N PapanikolaouK Patsialos

Abstract

Cyclosporine (CsA) (37.4 mumol/kg per day for 7 days) treated female Wistar rats exhibited significantly decreased creatinine clearance (Ccr) and body weight loss (BWL), but had neither proteinuria (PU) nor alteration in their urine volume (V). Light microscopic (LM) sections of rat kidneys showed that all kidneys were affected by lesions, mainly diffuse vacuolization. These changes were associated with decreased urinary excretion ratios of 6-ketoprostaglandin F1 alpha to thromboxane B2 (6kPGF1 alpha/TXB2) and prostaglandin E2 to TXB2 (PGE2/TXB2). When OKY-046, a TXA2-synthetase inhibitor or nifedipine (NFD), a calcium channel blocker and an antagonist of endotheline (ET), were administered in addition to CsA, they restored Ccr and increased urine V but they did not prevent BWL. LM sections showed that only 5 or 7 out of 9 kidneys of animals were affected, respectively. These changes were associated with prevention of the diminished ratios of urinary PGE2/TXB2 and 6kPGF1 alpha/TXB2 mainly in the OKY-046 treated animals. In conclusion, our results suggest that inhibitors of TXA2 or antagonists and/or inhibitors of endothelin play a protective role in the development of the dysfunction induced by CsA. However, the protection obse...Continue Reading

References

Nov 1, 1978·Clinical Science and Molecular Medicine·R WerbA L Linton
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Feb 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N PapanikolaouJ Bariety
May 1, 1991·American Journal of Obstetrics and Gynecology·G Fried, U Samuelson
Jul 1, 1991·The Journal of Clinical Investigation·T E Bunchman, C A Brookshire
Jun 1, 1990·Kidney International·V KonR L Hoover
Sep 14, 1989·Nature·N Bosworth, P Towers
Jun 15, 1986·Experientia·C Hatziantoniou, N Papanikolaou
Sep 1, 1986·Clinical Immunology and Immunopathology·N HinglaisP Druet
Sep 1, 1985·Prostaglandins, Leukotrienes, and Medicine·T NiwaK Yamada
Oct 1, 1972·Kidney International·P Kincaid-Smith
Apr 1, 1982·Prostaglandins, Leukotrienes, and Medicine·A K Mandal, J Miller
Jan 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P MorphakeN Papanikolaou
Mar 1, 1993·Clinical Immunology and Immunopathology·G J Prud'homme, L E Vanier

❮ Previous
Next ❯

Citations

Aug 15, 2014·Clinical and Experimental Pharmacology & Physiology·Viginie VoisinNathalie Caron
Jun 22, 2001·Prostaglandins, Leukotrienes, and Essential Fatty Acids·I E Darlametsos, D D Varonos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.