Effects of olanexidine gluconate on preoperative skin preparation: an experimental study in cynomolgus monkeys

Journal of Medical Microbiology
Hikaru NakataTadashi Imamura

Abstract

To determine the bactericidal efficacy of a new topical antiseptic for preoperative skin preparation, olanexidine gluconate (development code: OPB-2045G), against transient or resident bacterial flora on the skin of cynomolgus monkeys. After measuring baseline bacterial counts on test sites marked on the abdomens, we applied olanexidine, chlorhexidine or povidone-iodine. After 10 min (fast-acting effect) and 6 h (long-lasting effect), bacterial counts were measured again and log10 reductions were calculated. In addition, we determined the bactericidal effects on the skin contaminated with blood before or after applying the antiseptics. In the non-blood-contaminated condition, the mean log10 reductions of olanexidine at doses of 1-2 % were significantly higher than those of saline (negative control), but did not significantly differ from those of 0.5 % chlorhexidine and 10 % povidone-iodine at either time point. But olanexidine was significantly more effective at both time points than chlorhexidine and povidone-iodine when applied after the site was contaminated with blood. Olanexidine was also significantly more effective than chlorhexidine and as effective as or more effective than povidone-iodine at both time points when skin...Continue Reading

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Citations

Dec 21, 2018·Biological & Pharmaceutical Bulletin·Shoji SeyamaNorihisa Noguchi
Nov 11, 2019·BMC Oral Health·Takuya NiiYoichiro Miyake
Mar 4, 2020·Food and Environmental Virology·Kaoru ImaiDaisuke Sano
Jul 20, 2021·International Heart Journal·Takahiro MatsumotoHiroyuki Daida

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