Effects of oligomeric grape seed proanthocyanidins on L-NAME-induced hypertension in pregnant mice: Role of oxidative stress and endothelial dysfunction

Phytotherapy Research : PTR
Feng-Qin ZhuShan Gao

Abstract

The aim of this study was to investigate the effects of Grape Seed Proanthocyanidins (GSP) on Nω-Nitro-L-arginine methyl ester-induced hypertension in pregnant mice. Fifty Kunming mice were randomized into control, control + GSP, model, and model + GSP. Three weeks later, the artery systolic blood pressure was examined and the related pathological changes were detected. Aorta relaxation function was assessed by aorta ring apparatus. Blood urea nitrogen and serum creatinine were measured by an automatic biochemistry analyzer. Colorimetric analysis, enzyme-linked immunosorbent assay, immunofluorescence, and western blot were applied to detect related indicator in serum, cardiac, and kidney tissues. The results showed that GSP treatment for 3 weeks could improve cardiovascular and kidney remodeling indexes and decrease blood urea nitrogen and serum creatinine content in serum, as well as could ameliorate oxidative stress status and endothelial dysfunction. Therefore, it is for the first time found that GSP exerts protective effect against Nω-Nitro-L-arginine methyl ester-induced hypertension in pregnant mice, which provided a theoretical basis for potential application in the clinic.

References

Mar 1, 1993·Hypertension·J DananbergR J Grekin
Feb 1, 1996·Acta Obstetricia Et Gynecologica Scandinavica·J M YangK G Wang
Feb 24, 2001·Molecular and Cellular Biochemistry·S Qanungo, M Mukherjea
Aug 12, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·James M RobertsUNKNOWN National Heart Lung and Blood Institute
Feb 6, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Esther Granot, Ron Kohen
Dec 15, 2004·Trends in Cardiovascular Medicine·Keith M Channon
Sep 27, 2006·The American Journal of Medicine·Andrea GalassiJiang He
Feb 7, 2009·Physiology·George Osol, Maurizio Mandala
Feb 19, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Timothy R NurkiewiczMatthew A Boegehold
Sep 13, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jia-Yin FuQiang Xia
Dec 27, 2011·Redox Report : Communications in Free Radical Research·Claudio A M LealJeandre Augusto Dos Santos Jaques
Feb 13, 2013·Circulation·Tuija MännistöEila Suvanto
Aug 6, 2013·Current Hypertension Reports·Rebecca C MoorhouseNeeraj Dhaun
Nov 14, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shamima AkterYuhei Kawano
Apr 22, 2015·Journal of Molecular and Cellular Cardiology·Adam HarveyRhian M Touyz
May 6, 2015·The Journal of Nutritional Biochemistry·Ling-ling HuangShan Gao
Apr 15, 2016·Reproductive Sciences·Yuan LiXietong Wang
Jun 28, 2017·BMC Complementary and Alternative Medicine·Juan HuShan Gao
Jan 20, 2018·Cancer Causes & Control : CCC·Delphine PraudMarta Rossi

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Citations

Apr 7, 2020·Hypertension·Kathryn L GatfordAlison S Care
Dec 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tsz Ki WangYunjian Zhang
Nov 27, 2020·Frontiers in Physiology·Teresa TropeaElizabeth C Cottrell

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