Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions

The American Journal of Cardiology
James H O'KeefeWilliam S Harris

Abstract

We explored possible mechanisms by which recommended intakes of omega-3 fatty acids may decrease the risk for sudden cardiac death in patients with documented coronary heart disease. The cardioprotective effects of omega-3 fatty acids have been documented in epidemiologic and randomized controlled trials. These fatty acids are presumed to decrease susceptibility to fatal arrhythmias, but whether this is mediated by classic risk factors or direct cardiac mechanisms is not known. Eighteen white men with a history of myocardial infarction and ejection fractions <40% were randomized to placebo or omega-3 fatty acids (585 mg of docosahexaenoic acid and 225 mg of eicosapentaenoic acid) for two 4-month periods in a crossover design. At the end of each period, heart rate (HR), HR variability, and rate of HR recovery after exercise were determined, as were effects on arterial compliance, blood pressure, cardiac function, and fasting serum levels of lipids and inflammatory markers. Omega-3 fatty acids decreased HR at rest from 73 +/- 13 to 68 +/- 13 beats/min (p <0.0001) and improved 1-minute HR recovery after exercise (-27 +/- 10 to -32 +/- 12 beats/min, p <0.01). HR variability in the high-frequency band increased (p <0.02), but no cha...Continue Reading

Associated Clinical Trials

References

Nov 20, 2002·Circulation·Penny M Kris-EthertonUNKNOWN American Heart Association. Nutrition Committee
Sep 21, 2005·Circulation·Dariush MozaffarianMartijn B Katan

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Citations

Jun 20, 2008·European Journal of Applied Physiology·Buddy Walser, Charles L Stebbins
Oct 22, 2008·Current Atherosclerosis Reports·Konstantinos TziomalosDimitri P Mikhailidis
Oct 27, 2009·Current Atherosclerosis Reports·Roberto MarchioliRaffaella Pioggiarella
Sep 10, 2008·The British Journal of Nutrition·Sanéo ThioubFrançois Guerrero
Aug 13, 2010·Seminars in Dialysis·Allon N Friedman
Oct 6, 2009·Fiziologiia cheloveka·S A Kryzhanovskiĭ, M B Vititnova
Apr 5, 2011·American Journal of Physiology. Heart and Circulatory Physiology·George E Billman, William S Harris
Jan 26, 2010·American Journal of Physiology. Heart and Circulatory Physiology·George E BillmanPaul M L Janssen
Jan 25, 2013·Cardiology Research and Practice·Norbert GüttlerAndreas Böning
Jan 16, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David J A JenkinsStephen C Cunnane
Jan 5, 2011·Journal of Multidisciplinary Healthcare·Giacomo LevantesiRoberto Marchioli
Feb 1, 2009·Biomarkers in Medicine·Clemens von Schacky
Nov 10, 2012·World Journal of Gastroenterology : WJG·Matteo Nicola Dario Di MinnoGiovanni Tarantino
Jul 23, 2013·Indian Journal of Endocrinology and Metabolism·Soumia PeterJubbin J Jacob
Oct 31, 2014·The British Journal of Nutrition·Michael J MacartneyPeter L McLennan
Oct 27, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Asgeir Graesdal
May 18, 2010·Expert Opinion on Investigational Drugs·Gregory C MakrisMatthew E Falagas
Apr 15, 2015·Vascular Pharmacology·Maria Teresa La Rovere, Jeppe Hagstrup Christensen
Jul 20, 2010·Lancet·Palaniappan SaravananPhilip C Calder
May 25, 2010·Epilepsy & Behavior : E&B·Susan W Lee, Steve S Chung
Sep 1, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Arie O VerkerkRuben Coronel
Jul 21, 2009·Progress in Cardiovascular Diseases·Paolo Palatini
Jun 13, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Clemens von Schacky
Mar 5, 2008·Mayo Clinic Proceedings·John H LeeWilliam S Harris
Jun 26, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·My SvenssonJeppe H Christensen
Jul 3, 2007·Pathophysiology : the Official Journal of the International Society for Pathophysiology·J FedackoV Vargová
Jul 21, 2010·Critical Care Clinics·Renee D StapletonKonstantin Mayer
Dec 1, 2006·The American Journal of Cardiology·William S HarrisA Michael Borkon
Mar 21, 2007·The American Journal of Cardiology·Harold E Bays

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