Effects of omega-3 polyunsaturated fatty acids on fibrosis, endothelial function and myocardial performance, in ischemic heart failure patients

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Evangelos OikonomouDimitris Tousoulis

Abstract

Polyunsaturated fatty acids (PUFAs) may affect the cardiovascular system with a multiplicity of mechanisms. We assessed the effects of omega-3 PUFAs supplements on inflammation, fibrosis, left ventricle performance and endothelial function of ischemic heart failure (HF) patients. In this double-blind, placebo controlled, cross-over trial we enrolled 31 patients with ischemic HF, followed by a 6-week wash-out period. Omega-3 PUFAs (2 g daily, 8 weeks) were administered PO in the intervention arm. Left ventricle ejection fraction (EF), global longitudinal strain and the ratio E/e' (early ventricular filling to early mitral annulus velocities)were measured. Endothelial function was evaluated by flow mediated dilation and myocardial fibrosis by soluble ST2. High sensitive C Reactive protein (hsCRP) levels were measured as an inflammatory marker. Treatment with omega-3 PUFA, compared to placebo, improved: left ventricle EF (percent increased by 4.7% vs 1.7%); global longitudinal strain (decreased by -10.6% vs -2.3%); the E/e' ratio (decreased by -9.47% vs -2.1%); ST2 levels (decreased by -4.53% vs -2.37%); flow mediated dilation (percent increased by 44% vs. 11% and hsCRP levels (decreased by -6.13% vs 4.35%) (p < 0.05 for all). Sho...Continue Reading

Citations

Aug 21, 2019·International Journal of Molecular Sciences·Atsushi SakamotoYuichiro Maekawa
Mar 17, 2020·Nutrition Research Reviews·Arrigo F G CiceroUNKNOWN International Lipid Expert Panel
Jan 23, 2019·Frontiers in Physiology·Alessandra AlíAdemuyiwa S Aromolaran
Dec 16, 2020·International Journal of Molecular Sciences·Stathis DimitropoulosDimitris Tousoulis
Oct 17, 2020·Oxidative Medicine and Cellular Longevity·Andy W C ManNing Xia
Feb 22, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mahnaz SalmaniHossein Imani
Aug 29, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Katharina LechnerFrank Edelmann

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