PMID: 8460756Feb 1, 1993Paper

Effects of omeprazole, with and without metoclopramide, in elective obstetric anaesthesia

Anaesthesia
D A OrrJ Moore

Abstract

We report the results of a study comparing two dose regimens of the gastric antisecretory agent, omeprazole, used as prophylaxis against pulmonary aspiration of gastric contents during general anaesthesia for elective Caesarean section. Since antisecretory agents do not clear stomach contents already present at the start of treatment, two groups of patients who had received both omeprazole and a prokinetic drug, metoclopramide, were also studied. Thirty patients received oral omeprazole 40 mg on the evening before and on the morning of the operation (group 1), 33 received oral omeprazole 80 mg on the morning of the operation (group 2), and 15 (group 3) and 16 (group 4) patients respectively received the oral omeprazole doses stated above and in addition metoclopramide 10 mg given intramuscularly at least 20 min before induction of anaesthesia. Gastric aspirate pH and volume were measured at induction of anaesthesia and on completion of surgery. At induction of anaesthesia, treatment was judged successful (pH > or = 2.5 and volume < 25 ml) in 87%, 73%, 100% and 81% of patients in groups 1-4 respectively. The corresponding results on completion of surgery were 100%, 88%, 100% and 100%. While omeprazole is useful as prophylaxis ag...Continue Reading

References

May 1, 1975·British Journal of Anaesthesia·G Taylor
Mar 1, 1978·British Journal of Anaesthesia·J G Brock-UtneJ W Downing
Mar 1, 1990·Therapeutic Drug Monitoring·C G RegårdhI Skånberg
Jul 1, 1989·Anaesthesia·H M Mathews, J Moore
Apr 1, 1987·Anaesthesia·J Thorburn, D D Moir
Jan 1, 1986·Developmental Pharmacology and Therapeutics·M S ChingR A Smallwood
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·B A PerssonI Grundevik
Sep 1, 1985·Canadian Anaesthetists' Society Journal·J G Stock, A D Sutherland
Sep 1, 1983·Canadian Anaesthetists' Society Journal·M Bylsma-HowellJ E Axelson
Feb 1, 1981·Anaesthesia·W McCaugheyJ W Dundee

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Citations

May 1, 1996·Anaesthesia·J C StuartT Gin
Sep 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A TripathiP Bajaj
Feb 18, 2009·Journal of Gastroenterology and Hepatology·Toru HiyamaKazuaki Chayama
Feb 6, 2014·The Cochrane Database of Systematic Reviews·Shantini ParanjothyJane Thomas
Mar 26, 1998·Anaesthesia and Intensive Care·M T Kluger, G Willemsen
Aug 5, 1998·Acta Anaesthesiologica Scandinavica·U M StamerH Wulf
Dec 12, 2012·Anaesthesia·L D Gray, C Morris
Aug 13, 2010·Acta Anaesthesiologica Scandinavica·A G JensenUNKNOWN Clinical Practice Committee of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine
Sep 14, 2012·The Cochrane Database of Systematic Reviews·James D GriffithsJane Thomas
May 19, 2021·The Cochrane Database of Systematic Reviews·James D GriffithsJane Thomas
Mar 15, 2003·Gastroenterology Clinics of North America·Mitchell S Cappell
Apr 18, 1998·Gastroenterology Clinics of North America·M S Cappell, A Garcia

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