Effects of ondansetron administration on opioid withdrawal syndrome observed in rats

European Journal of Pharmacology
A PinelliL Tomasoni

Abstract

This study tested whether a 5-HT3 receptor antagonist could reverse the signs of precipitated opioid withdrawal. Rats were treated with either saline or morphine for 4 days. After the four days, half of the rats in each group received naloxone and half received saline. Each animal also received one of four doses of ondansetron (0, 1, 2 and 4 mg/kg i.p.). Administration of ondansetron to rats receiving naloxone after chronic morphine decreased the intensity of withdrawal signs such as increased defecation, jumping and wet-dog shakes, elevated the nociceptive threshold values which were decreased by precipitated withdrawal, but produced no change in urination, rectal temperature or salivation. The effects exhibited by ondansetron administration may be explained through interference of its 5-HT3 receptor antagonist activity with serotoninergic mechanisms involved in the regulation of these withdrawal symptoms. The use of this drug is thus suggested as a possible treatment of opioid withdrawal signs in heroin addicts.

Associated Clinical Trials

Apr 18, 2008·Larry Fu-nien Chu, Larry Fu-nien Chu

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Citations

Jan 31, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Isolde BrosetaJosé Miñarro
May 9, 2002·Journal of Pain and Symptom Management·Natalia KhojainovaGilbert R Gonzales
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Jan 13, 2021·Cellular and Molecular Neurobiology·Lisa L WilsonJay P McLaughlin
Apr 30, 2021·Neuroscience·Ardeshir AkbarabadiMohammad-Reza Zarrindast

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