PMID: 3773644Nov 17, 1986Paper

Effects of opioid antagonists and their quaternary analogs on temperature changes in morphine-dependent rats

Life Sciences
M J KatovichJ O'Meara

Abstract

Subcutaneous administration of three opioid antagonists; naloxone, naltrexone and nalmefene, produced a significant rise in tail skin temperature and a subsequent fall in rectal temperature in morphine dependent rats. However, subcutaneous administration of equimolar concentrations of the quaternary derivatives of these opioid antagonists (naloxone methobromide, naltrexone methobromide and n-methylnalmefenium iodide) failed to produce any significant alterations in either tail skin or rectal temperatures in the morphine dependent rat. At doses of naloxone methobromide 6 to 9 times greater than naloxone, there was a slight reduction of rectal temperatures with no significant elevation of skin temperature. However, the fall in rectal temperature was still significantly less than that achieved with administration of naloxone. When each of these six agents were administered centrally (20 micrograms/5 microliter, icv) in the morphine dependent rat, similar increases in tail skin temperature and decreases in rectal temperature were observed. These temperature changes were similar to those observed following systemic administration of the opioid antagonist. Previously, we have suggested that acute withdrawal in the morphine-dependent ...Continue Reading

References

Nov 1, 1982·The Journal of Clinical Endocrinology and Metabolism·S L WardlawA G Frantz
Jul 1, 1980·Maturitas·I V TatarynH L Judd

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Citations

Jun 21, 1990·European Journal of Pharmacology·J Antonio MartínezM V Milanés
Nov 1, 1987·Peptides·G A OlsonA J Kastin
Jun 18, 2002·European Journal of Pharmacology·Tanya Lewanowitsch, Rodney J Irvine
Mar 30, 1999·European Journal of Pharmacology·R ChanJ White
Oct 1, 1996·Pharmacology, Biochemistry, and Behavior·B E Wright, M J Katovich
Aug 16, 2006·Expert Opinion on Drug Safety·Vincenzo De LeoFelice Petraglia

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