PMID: 2120527Jan 1, 1990Paper

Effects of opioid blockade with nalmefene in older impotent men

Life Sciences
C J BillingtonJ E Morley

Abstract

We evaluated the effect of the opioid antagonist nalmefene on the HPG axis and on food consumption in 14 older impotent men. These patients had low to low normal mean serum testosterone values and normal gonadotrophin levels on screening evaluation. Normal response to GnRH was demonstrated in all the men. The protocol called for 24 hours of evaluation before and during administration of nalmefene 2.0 mg IV every 8 hours for 3 doses. During each 24 hour period, the following determinations were made: serum testosterone, FSH, and LH by five separate determinations between 8 AM and noon; 8 AM and 11 PM serum cortisols; 24 hour urine collections for free cortisol; and nocturnal penile tumescence (NPT). Food consumption was measured from 4 PM to 10 AM during the two periods. Nalmefene resulted in significant rises in testosterone, LH, and FSH. Nalmefene significantly elevated morning and evening cortisol measurements in all the patients. Nalmefene decreased total calorie consumption, principally by decreasing fat consumption. There was no effect on NPT. We conclude that in older impotent men, nalmefene acutely increases activity of the HPG axis and decreases calorie intake predominantly by decreasing fat consumption.

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Citations

Jul 1, 1994·Neurobiology of Aging·F E Kaiser, J E Morley
Jul 6, 2000·Pharmacology, Biochemistry, and Behavior·N K MelloM Kelly
Apr 20, 2001·Maturitas·J E Morley
Jan 23, 2010·The Journal of Sexual Medicine·Christian GratzkeChristian G Stief
Jan 21, 2006·The Journal of Sexual Medicine·Harin Padma-NathanClaude Teloken
May 16, 2000·The Journal of Laboratory and Clinical Medicine·J E Morley, H M Perry
Jul 30, 1999·The American Journal of Clinical Nutrition·S S Yeh, M W Schuster
May 24, 2005·Reproduction, Fertility, and Development·Ma YuanZhang Yong-Xiang

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