Effects of opioids in the formalin test in the Speke's hinged tortoise (Kinixy's spekii)

Journal of Veterinary Pharmacology and Therapeutics
S N WambuguT I Kanui

Abstract

Little is known about analgesia in lower vertebrates such as the Speke's hinged tortoise (Kinixy's spekii), yet of late they are increasingly being adopted as pets. The effects of morphine (5, 7.5, 10 and 20 mg/kg), pethidine (10, 20, and 50 mg/kg) and naloxone (5 mg/kg) on nociception induced by the formalin test (12.5%, 100 microL) were studied in the Speke's hinged tortoise. Formalin induced a monophasic limb retraction behavioural response and its duration was recorded. The behaviour lasted for 16.4 +/- 0.8 min. Morphine (7.5, 10 and 20 mg/kg) and pethidine (20 and 50 mg/kg) induced significant decrease in the duration of limb retraction in the formalin test. The anti-nociceptive effects were naloxone (5 mg/kg) reversible. The data suggest that the formalin test is a good test for studying nociception and anti-nociception in tortoises and that the opioidergic system plays a role in the control of nociception in these animals.

References

Oct 1, 1992·Pain·A TjølsenK Hole
Mar 1, 1992·Journal of Veterinary Pharmacology and Therapeutics·T I Kanui, K Hole
Dec 1, 1988·Brain Research Bulletin·M Kavaliers
Jun 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·J P ChambersA Livingston
Sep 18, 1998·Brain Research·O HoffmannZ Wiesenfeld-Hallin
Nov 27, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J R Vane, R M Botting
May 22, 2003·Drug and Alcohol Dependence·Nancy A Ator, Roland R Griffiths
Mar 3, 2004·Journal of the American Veterinary Medical Association·Matt R Read
Mar 9, 2004·Journal of the American Veterinary Medical Association·Joanne Paul-MurphyPauline L Wong
Oct 7, 2004·Brain Research. Brain Research Reviews·Lynne U Sneddon
Apr 25, 2006·The Journal of Pain : Official Journal of the American Pain Society·Michael M MorganMelissa M King
May 3, 2007·Journal of the American Veterinary Medical Association·Kurt K SladkyStephen M Johnson
Mar 12, 2008·Brain Research Bulletin·Ann B Butler
Aug 1, 2002·Integrative and Comparative Biology·R Glenn Northcutt

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Citations

Oct 23, 2012·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Christoph MansKurt K Sladky
Oct 12, 2013·Diseases of Aquatic Organisms·Antonio Di BelloDelia Franchini

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