May 1, 1978

Effects of optical isomers of verapamil on SA nodal pacemaker activity and contractility of the isolated dog heart

Japanese Heart Journal
S ChibaY Furukawa

Abstract

Using 10 isolated, blood-perfused canine atrial, and ventricular preparations, the effects of d- and l-verapamil on SA nodal pacemaker activity and contractility were investigated. l-verapamil and d-verapamil produced dose-related negative chronotropic and inotropic effects in all experiments. l-verapamil was approximately 10 time more potent than d-verapamil both in inotropism and chronotropism. Negative inotropism of either d- or l-verapamil can be reversed by injection of calcium chloride. Not only d-verapamil but also l-verapamil produced a stronger suppression at higher frequencies in both atrial and ventricular muscles.

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Mentioned in this Paper

Sinoatrial Node
Myocardial Contraction
Depression, Chemical
Myopathy
Atrial Fibrillation
Visual Suppression
Calcium Chloride, Anhydrous
Body Surface Area Formula for Dogs
Atrial Function
NODAL gene

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