Effects of oral administration of metronidazole on small intestinal bacteria and nutrients of cats

American Journal of Veterinary Research
K L JohnstonR M Batt

Abstract

To determine effects of oral administration of metronidazole on the number and species of duodenal bacteria and selective nutrients of cats. 6 healthy domestic shorthair cats. Undiluted duodenal fluid was obtained for quantitative and qualitative bacterial culture to determine species and number of bacteria in healthy cats. Blood samples were assayed for taurine, total protein, albumin, cobalamin, and folate concentrations. Cats then were given metronidazole (20 mg/kg of body weight, PO, q 12 h) for 1 month, after which bacterial cultures and serum assays of nutrients were repeated. Nine months after cessation of antibiotic treatment, duodenal bacteria were re-evaluated and serum was assayed for total protein, albumin, cobalamin, and folate concentrations. Oral administration of metronidazole caused a significant decrease in aerobic and anaerobic bacterial counts in the duodenum of healthy cats, accompanied by emergence of Streptococcus spp and Corynebacterium spp. Serum concentrations of cobalamin and albumin increased when duodenal bacterial counts were decreased, although changes in folate or taurine concentrations were not detected. Measured variables did not differ, when comparing results obtained before and 9 months after...Continue Reading

References

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Citations

Jan 22, 2009·Journal of Feline Medicine and Surgery·Ivana SekisKenneth W Simpson
Aug 3, 2012·Animal Health Research Reviews·Yasushi MinamotoJan S Suchodolski
Feb 24, 2001·American Journal of Veterinary Research·K L JohnstonR M Batt
Aug 28, 2015·The Journal of Veterinary Medical Science·Kazuki HaradaTakae Shimizu
May 21, 2011·Topics in Companion Animal Medicine·Olivier Dossin
Oct 31, 2012·Journal of Veterinary Pharmacology and Therapeutics·Mark G PapichR B Hayes
Jan 4, 2005·The Veterinary Clinics of North America. Small Animal Practice·S A Center
Mar 29, 2019·Journal of Feline Medicine and Surgery·Sandra J StrongRon E Banks
Aug 15, 2020·Frontiers in Microbiology·Yang LyuMyriam Hesta
Feb 12, 2017·The Journal of Small Animal Practice·T Krentz, S Allen
Nov 3, 2020·The Veterinary Clinics of North America. Small Animal Practice·Anna-Lena Ziese, Jan S Suchodolski

Related Concepts

Metazoa
Bacteriocidal Agents
Serum Proteins
Felis catus
Duodenum
Folate
Bayer 5360
Plasma Albumin
Taurine, Monopotassium Salt
Eritron

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