Effects of oral aluminum on essential trace elements metabolism during pregnancy

Biological Trace Element Research
M BellésJosé L Domingo

Abstract

The present study was conducted to assess in rats the effects of oral aluminum (Al) exposure on calcium (Ca), magnesium (Mg), manganese (Mn), copper (Cu), zinc (Zn), and iron (Fe) accumulation and urinary excretion. Three groups of plug-positive Sprague-Dawley (SD) rats were given by gavage 0, 200, and 400 mg/kg/d of Al(OH)3 on gestational days 1-20. Three groups of nonpregnant female SD rats of the same age received Al(OH)3 by gavage at the same doses for 20 consecutive days. At the end of the treatment period, 24-h urine samples were collected for analysis of Al and essential elements. Subsequently, all animals were sacrificed and samples of liver, bone, spleen, kidneys, and brain were removed for metal analyses. With some exceptions, the urinary amounts of Al, Mn, and Cu excreted by pregnant animals as well as the urinary levels of Al excreted by nonpregnant rats were higher in the Al-treated groups than in the respective control groups. Although higher Al levels were found in the liver of pregnant rats, the concentrations of Al in the brain of these animals were lower than those found in the same tissues of nonpregnant rats. With regard to the essential elements, tissue accumulation was most affected in pregnant than in non...Continue Reading

Citations

Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Aug 19, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M J González-MuñozI Meseguer
Apr 22, 2015·Toxicology and Industrial Health·Ben WangYanfei Li
Jul 18, 2018·International Journal of Environmental Research and Public Health·Halina B RöllinJon Ø Odland
Oct 13, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Gasem Mohammad Abu-Taweel, Mohsen Ghaleb Al-Mutary

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