Effects of oral and inhaled corticosteroid on lymphocyte beta2-adrenoceptor function in asthmatic patients

British Journal of Clinical Pharmacology
K S TanB J Lipworth

Abstract

We have previously demonstrated that a single dose of oral prednisolone but not single doses of inhaled fluticasone had facilitatory effects on lymphocyte beta2-adrenoceptor (AR) function. To address possible differences in steady-state time-course, the aim of this study was to determine if repeated dosing with inhaled fluticasone would have facilitatory effects on lymphocyte beta2-AR. Plasma cortisol was also evaluated as a measure of systemic bioactivity. Ten asthmatic subjects, mean (s.e.mean) age 29 (3) years, FEV1 89 (5) % predicted, were randomised in a double-blind crossover study to receive inhaled placebo (PL), inhaled fluticasone 1000 microg day-1 (F1000) and inhaled fluticasone 2000 microg day-1, each for 4 days and also a single dose of oral prednisolone 50 mg (PRED). Prednisolone was given as open medication. The last dose of study drug was taken at 22.00 h and subjects attended the laboratory at 08.00 h the following day. beta2-AR density (Bmax; fmol/10[6] cells) was significantly increased after PRED compared with PL and inhaled fluticasone. Bmax (geometric mean) after each treatment were: PL 1.51, F1000 1.20, F2000 1.20 and PRED 2.14 (a 1.4 fold difference PRED vs PL; 95% CI 1.05 to 1.95; P < 0.001). There was s...Continue Reading

Citations

Nov 24, 2004·American Journal of Respiratory and Critical Care Medicine·Shweta ChoudhryEsteban González Burchard
Sep 19, 2002·British Journal of Clinical Pharmacology·Brian J Lipworth
Jul 9, 2005·American Journal of Respiratory and Critical Care Medicine·G R G Todd
Jan 21, 2006·Critical Care Medicine·Ainsley M SutherlandJames A Russell
Nov 9, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Rohit VohraSuresh Gupta

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